Amyloid-β (Aβ) peptides play a key role in the pathogenesis of Alzheimer's disease and exert
various toxic effects on neurons; however, relatively little is known about their influence on …

The key pathogenic event in the onset of Alzheimer's disease (AD) is the aggregation of β‐amyloid
(Aβ) peptides into toxic aggregates. Molecules that interfere with this process might …

Background and purpose Second mitochondria-derived activator of caspase (SMAC)-mimetics
are a new class of targeted drugs that specifically induce apoptotic cancer cell death and …

Although the assembly of a ternary complex between the SNARE proteins syntaxin-1, SNAP25
and VAMP2 is known to be crucial for insulin exocytosis, the mechanisms controlling this …

Glutaric aciduria type I (GA-I, OMIM # 231670 ) is an autosomal recessive inborn error of
metabolism caused by deficiency of the mitochondrial enzyme glutaryl-CoA dehydrogenase (…

The p120 RasGAP protein negatively regulates Ras via its GAP domain. RasGAP carries
several other domains that modulate several signaling molecules such as Rho. RasGAP is …

Metabolic syndrome (MetS) refers to cardiometabolic risk factors, such as visceral obesity,
dyslipidemia, hyperglycemia/insulin resistance, arterial hypertension and non-alcoholic fatty …

Purpose Endosialin/tumor endothelial marker-1 (TEM1) is an attractive theranostic target
expressed by the microenvironment of a wide range of tumors, as well as by sarcoma and …

Antibodies are an attractive therapeutic modality for cancer treatment as they allow the
increase of the treatment response rate and avoid the severe side effects of chemotherapy. …

Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET
and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range …