Background Concurrent treatment with temozolomide and radiotherapy followed by maintenance
temozolomide is the standard of care for patients with newly diagnosed glioblastoma. …

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

… Wen, Tom Mikkelsen, David Schiff, Lauren E. Abrey, WK Alfred Yung, Nina Paleologos,
Martin K. Nicholas, Randy Jensen, James Vredenburgh, Jane Huang, Maoxia Zheng, and …

CNS metastases are the most common cause of malignant brain tumours in adults. Historically,
patients with brain metastases have been excluded from most clinical trials, but their …

PURPOSE: NovoTTF-100A is a portable device delivering low-intensity, intermediate
frequency electric fields via non-invasive, transducer arrays. Tumour Treatment Fields (TTF), a …

Purpose To provide guidance to clinicians regarding therapy for patients with brain
metastases from solid tumors. Methods ASCO convened an Expert Panel and conducted a …

Although low-grade gliomas (LGG) have a less aggressive course than do high-grade gliomas,
the outcome of these tumours is ultimately fatal in most patients. Both the tumour and its …

Purpose Cilengitide, an inhibitor of v3 and v5 integrin receptors, demonstrated minimal
toxicity and durable activity across a wide range of doses administered to adults with recurrent …

MicroRNA-34a (miR-34a) is a transcriptional target of p53 that is down-regulated in some
cancer cell lines. We studied the expression, targets, and functional effects of miR-34a in brain …

Evolving interest in meningioma, the most common primary brain tumor, has refined
contemporary management of these tumors. Problematic, however, is the paucity of prospective …