10.7554/eLife.18638.001 Heat shock factor (Hsf1) regulates the expression of molecular
chaperones to maintain protein homeostasis. Despite its central role in stress resistance, …

Secretory and transmembrane proteins enter the endoplasmic reticulum (ER) as unfolded
proteins and exit as either folded proteins in transit to their target organelles or as misfolded …

While many books have discussed methodological advances in nonlinear dynamical
systems theory (NDS), this volume is unique in its focus on NDS's role in the development of …

The application of all‐atom force fields (and explicit or implicit solvent models) to protein
homology‐modeling tasks such as side‐chain and loop prediction remains challenging both …

Enzymatic substrates are powerful tools in biochemistry. They are widely used in microbiology
to study metabolic pathways, to monitor metabolism and to detect, enumerate and identify …

Choanoflagellates are the closest known relatives of metazoans. To discover potential
molecular mechanisms underlying the evolution of metazoan multicellularity, we sequenced and …

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)
has revolutionized the identification of microbial species in clinical microbiology …

The beclin 1 (BECN1) gene encodes a 60-kDa coiled-coil protein that interacts with the
prototypic apoptosis inhibitor Bcl-2. Previous studies indicate that beclin 1 maps to a region …

The unfolded protein response (UPR) is an intracellular signaling pathway that counteracts
variable stresses that impair protein folding in the endoplasmic reticulum (ER). As such, the …

Deficiencies in the protein-folding capacity of the endoplasmic reticulum (ER) in all eukaryotic
cells lead to ER stress and trigger the unfolded protein response (UPR) 1 , 2 , 3 . ER stress …