User profiles for David Komatsu

David E. Komatsu

Department of Orthopaedics and Rehabilitation, Stony Brook University
Verified email at sbumed.org
Cited by 2124

Modulation of Wnt signaling influences fracture repair

DE Komatsu, MN Mary, RJ Schroeder… - Journal of …, 2010 - Wiley Online Library
While the importance of Wnt signaling in skeletal development and homeostasis is well
documented, little is known regarding its function in fracture repair. We hypothesized that …

[HTML][HTML] Low-intensity continuous ultrasound therapies—a systematic review of current state-of-the-art and future perspectives

SMZ Uddin, DE Komatsu, T Motyka… - Journal of clinical …, 2021 - mdpi.com
Therapeutic ultrasound has been studied for over seven decades for different medical
applications. The versatility of ultrasound applications are highly dependent on the frequency, …

The control of fracture healing and its therapeutic targeting: improving upon nature

DE Komatsu, SJ Warden - Journal of cellular biochemistry, 2010 - Wiley Online Library
Fracture repair is a complex process involving timed cellular recruitment, gene expression,
and synthesis of compounds that regenerate native tissue to restore the mechanical integrity, …

Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF‐1α deficiency

DE Komatsu, M Bosch‐Marce… - Journal of Bone and …, 2007 - academic.oup.com
HIF‐1α activates genes under hypoxia and was hypothesized to regulate bone regeneration.
Surprisingly, HIF‐1α +/− fracture calluses are larger, stronger, and stiffer than HIF‐1α +/+ …

Knotless suture anchor with suture tape quadriceps tendon repair is biomechanically superior to transosseous and traditional suture anchor–based repairs in a …

MC Kindya, J Konicek, A Rizzi, DE Komatsu… - Arthroscopy: The Journal …, 2017 - Elsevier
Purpose To compare the biomechanical properties of a knotless suture anchor with suture
tape quadriceps tendon repair technique with transosseous and suture anchor repair …

Biomechanical comparison of spinopelvic fixation constructs: iliac screw versus S2-alar-iliac screw

CB Burns, K Dua, NA Trasolini, DE Komatsu, JM Barsi - Spine deformity, 2016 - Elsevier
Study Design Biomechanical cadaveric study. Objective To compare the biomechanical
properties of the iliac and S2-Alar-Iliac (S2AI) screw in a similar spinopelvic fixation construct. …

[HTML][HTML] Chondro-protective effects of low intensity pulsed ultrasound

…, Y Ding, A Hettinghouse, DE Komatsu… - Osteoarthritis and …, 2016 - Elsevier
Objectives Cartilage is a highly mechano-responsive tissue. Chondrocytes undergo a
series of complex changes, including proliferation and metabolic alteration as the target of …

Recombinant human parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing

SJ Warden, DE Komatsu, J Rydberg, JL Bond… - Bone, 2009 - Elsevier
Fracture healing is thought to be naturally optimized; however, recent evidence indicates
that it may be manipulated to occur at a faster rate. This has implications for the duration of …

The therapeutic potential of microRNAs as orthobiologics for skeletal fractures

M Hadjiargyrou, DE Komatsu - Journal of Bone and Mineral …, 2019 - academic.oup.com
The repair of a fractured bone is critical to the well‐being of humans. Failure of the repair
process to proceed normally can lead to complicated fractures, exemplified by either a delay in …

A pharmacokinetic model of oral methylphenidate in the rat and effects on behavior

…, T Cooper, JM Swanson, DE Komatsu… - Pharmacology …, 2015 - Elsevier
Most animal studies using methylphenidate (MP) do not administer it the same way it is
administered clinically (orally), but rather by injection, resulting in an altered pharmacokinetic …