User profiles for David Komatsu
David E. KomatsuDepartment of Orthopaedics and Rehabilitation, Stony Brook University Verified email at sbumed.org Cited by 2124 |
Modulation of Wnt signaling influences fracture repair
DE Komatsu, MN Mary, RJ Schroeder… - Journal of …, 2010 - Wiley Online Library
While the importance of Wnt signaling in skeletal development and homeostasis is well
documented, little is known regarding its function in fracture repair. We hypothesized that …
documented, little is known regarding its function in fracture repair. We hypothesized that …
[HTML][HTML] Low-intensity continuous ultrasound therapies—a systematic review of current state-of-the-art and future perspectives
SMZ Uddin, DE Komatsu, T Motyka… - Journal of clinical …, 2021 - mdpi.com
Therapeutic ultrasound has been studied for over seven decades for different medical
applications. The versatility of ultrasound applications are highly dependent on the frequency, …
applications. The versatility of ultrasound applications are highly dependent on the frequency, …
The control of fracture healing and its therapeutic targeting: improving upon nature
DE Komatsu, SJ Warden - Journal of cellular biochemistry, 2010 - Wiley Online Library
Fracture repair is a complex process involving timed cellular recruitment, gene expression,
and synthesis of compounds that regenerate native tissue to restore the mechanical integrity, …
and synthesis of compounds that regenerate native tissue to restore the mechanical integrity, …
Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF‐1α deficiency
DE Komatsu, M Bosch‐Marce… - Journal of Bone and …, 2007 - academic.oup.com
HIF‐1α activates genes under hypoxia and was hypothesized to regulate bone regeneration.
Surprisingly, HIF‐1α +/− fracture calluses are larger, stronger, and stiffer than HIF‐1α +/+ …
Surprisingly, HIF‐1α +/− fracture calluses are larger, stronger, and stiffer than HIF‐1α +/+ …
Knotless suture anchor with suture tape quadriceps tendon repair is biomechanically superior to transosseous and traditional suture anchor–based repairs in a …
MC Kindya, J Konicek, A Rizzi, DE Komatsu… - Arthroscopy: The Journal …, 2017 - Elsevier
Purpose To compare the biomechanical properties of a knotless suture anchor with suture
tape quadriceps tendon repair technique with transosseous and suture anchor repair …
tape quadriceps tendon repair technique with transosseous and suture anchor repair …
Biomechanical comparison of spinopelvic fixation constructs: iliac screw versus S2-alar-iliac screw
Study Design Biomechanical cadaveric study. Objective To compare the biomechanical
properties of the iliac and S2-Alar-Iliac (S2AI) screw in a similar spinopelvic fixation construct. …
properties of the iliac and S2-Alar-Iliac (S2AI) screw in a similar spinopelvic fixation construct. …
[HTML][HTML] Chondro-protective effects of low intensity pulsed ultrasound
…, Y Ding, A Hettinghouse, DE Komatsu… - Osteoarthritis and …, 2016 - Elsevier
Objectives Cartilage is a highly mechano-responsive tissue. Chondrocytes undergo a
series of complex changes, including proliferation and metabolic alteration as the target of …
series of complex changes, including proliferation and metabolic alteration as the target of …
Recombinant human parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing
SJ Warden, DE Komatsu, J Rydberg, JL Bond… - Bone, 2009 - Elsevier
Fracture healing is thought to be naturally optimized; however, recent evidence indicates
that it may be manipulated to occur at a faster rate. This has implications for the duration of …
that it may be manipulated to occur at a faster rate. This has implications for the duration of …
The therapeutic potential of microRNAs as orthobiologics for skeletal fractures
M Hadjiargyrou, DE Komatsu - Journal of Bone and Mineral …, 2019 - academic.oup.com
The repair of a fractured bone is critical to the well‐being of humans. Failure of the repair
process to proceed normally can lead to complicated fractures, exemplified by either a delay in …
process to proceed normally can lead to complicated fractures, exemplified by either a delay in …
A pharmacokinetic model of oral methylphenidate in the rat and effects on behavior
…, T Cooper, JM Swanson, DE Komatsu… - Pharmacology …, 2015 - Elsevier
Most animal studies using methylphenidate (MP) do not administer it the same way it is
administered clinically (orally), but rather by injection, resulting in an altered pharmacokinetic …
administered clinically (orally), but rather by injection, resulting in an altered pharmacokinetic …