User profiles for David Klimstra

David Klimstra

Memorial Sloan Kettering Cancer Center
Verified email at mskcc.org
Cited by 100959

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

…, HI Scher, PJ Sabbatini, ME Robson, DS Klimstra… - Nature medicine, 2017 - nature.com
Tumor molecular profiling is a fundamental component of precision oncology, enabling the
identification of genomic alterations in genes and pathways that can be targeted …

[PDF][PDF] Integrated genomic characterization of pancreatic ductal adenocarcinoma

…, MS Lawrence, V Adsay, G Petersen, D Klimstra… - Cancer cell, 2017 - cell.com
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

[PDF][PDF] Organoid models of human and mouse ductal pancreatic cancer

…, SD Leach, DJ Pappin, M Hammell, DS Klimstra… - Cell, 2015 - cell.com
Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited
response to treatment. Tractable methods to identify and interrogate pathways involved in …

Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry

…, D Pan, D Schrag, L Schwartz, DS Klimstra… - Journal of clinical …, 2005 - ascopubs.org
Purpose To establish evidence of activity, or lack thereof, of cetuximab-based therapy in
patients with refractory colorectal cancer with tumors that do not demonstrate epidermal growth …

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

Y Jiao, C Shi, BH Edil, RF De Wilde, DS Klimstra… - Science, 2011 - science.org
Pancreatic neuroendocrine tumors (PanNETs) are a rare but clinically important form of
pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic …

Clinical-grade computational pathology using weakly supervised deep learning on whole slide images

…, KJ Busam, E Brogi, VE Reuter, DS Klimstra… - Nature medicine, 2019 - nature.com
The development of decision support systems for pathology and their deployment in clinical
practice have been hindered by the need for large manually annotated datasets. To …

[HTML][HTML] The 2019 WHO classification of tumours of the digestive system

ID Nagtegaal, RD Odze, D Klimstra, V Paradis… - …, 2020 - ncbi.nlm.nih.gov
The WHO classification of digestive system tumours presented in the first volume of the
WHO classification of tumours series, 5th edition, reflects important advancements in our …

Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

…, SN Goodman, SE Kern, DS Klimstra… - The American journal …, 2001 - journals.lww.com
Proliferative epithelial lesions in the smaller caliber pancreatic ducts and ductules have been
the subject of numerous morphologic, clinical, and genetic studies; however, a standard …

The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems

DS Klimstra, IR Modlin, D Coppola, RV Lloyd, S Suster - Pancreas, 2010 - journals.lww.com
Neuroendocrine tumors (NETs) arise in most organs of the body and share many common
pathologic features. However, a variety of different organ-specific systems have been …

Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma

…, EC Burke, J Bodniewicz, M Youssef, D Klimstra… - Annals of …, 2001 - journals.lww.com
Objective To analyze resectability and survival in patients with hilar cholangiocarcinoma
according to a proposed preoperative staging scheme that fully integrates local, tumor-related …