The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

We report a redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters
using an Ir photocatalyst under visible light irradiation. The method provides access to a …

The programmed death protein (PD-1) and its ligand (PD-L1) play critical roles in a checkpoint
pathway cancer cells exploit to evade the immune system. A same-day PET imaging …

Photophysical properties of a series of tetramethylrosamine dyes in which the xanthylium
oxygen atom has been replaced with sulfur or selenium were examined. Dyes with sulfur and, …

Thio and seleno analogues of tetramethylrosamine were prepared by the directed-metalation/cyclization
of the corresponding N,N-diethyl 2-(3-dimethylaminophenylchalcogeno)-4-…

Cancer immunotherapy, unlike traditional cytotoxic chemotherapeutic treatments, engages
the immune system to identify cancer cells and stimulate immune responses. The …

The first tellurium-containing analogues of the rosamine and rhodamine dyes were prepared
by the addition of Grignard or organolithium reagents to telluroxanthone precursors. The …

Blocking the interaction of the immune checkpoint molecule programmed cell death protein-1
and its ligand, PD-L1, using specific antibodies has been a major breakthrough for …

Three new positron emission tomography (PET) radiotracers of interest to our functional
neuroimaging and translational oncology programs have been prepared through new …

Positron emission tomography (PET) is an important non-invasive tool to help guide the
drug discovery and development process. Positron-emitting–radiolabeled drug candidates …