Objective: To review the underlying pathophysiologic processes of concussive brain injury
and relate these neurometabolic changes to clinical sports-related issues such as injury to the …

Since the original descriptions of postconcussive pathophysiology, there has been a
significant increase in interest and ongoing research to study the biological underpinnings of …

✓ An increase in extracellular K + concentration ([K + ] e ) of the rat hippocampus following
fluid-percussion concussive brain injury was demonstrated with microdialysis. The role of …

Traumatic brain injury (TBI) remains a major public health problem globally. In the United
States the incidence of closed head injuries admitted to hospitals is conservatively estimated to …

✓ Experimental traumatic brain injury studies have shown that cerebral hyperglycolysis is a
pathophysiological response to injury-induced ionic and neurochemical cascades. This …

Brain trauma is accompanied by regional alterations of brain metabolism, reduction in metabolic
rates and possible energy crisis. We hypothesize that microdialysis markers of energy …

Concussion (or mild traumatic brain injury, mTBI) is a biomechanically induced neurological
injury, resulting in an alteration of mental status, such as confusion or amnesia, which may …

Following cerebral concussion, in which there is no evidence of direct morphological damage,
cells are exposed to an increase in extracellular potassium as well as an accumulation of …

This article comprehensively reviews the lateral fluid percussion (LFP) model of traumatic
brain injury (TBI) in small animal species with particular emphasis on its validity, clinical …

Object. The early pathophysiological features of traumatic brain injury observed in the intensive
care unit (ICU) have been described in terms of altered cerebral blood flow, altered brain …