Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

…, SJJ Brouns, E Charpentier, D Cheng… - Nature Reviews …, 2020 - nature.com
The number and diversity of known CRISPR–Cas systems have substantially increased in
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas …

Clinical relevance of biomarkers of oxidative stress

…, SS Davies, R Stocker, D Cheng… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Oxidative stress is considered to be an important component of various diseases.
A vast number of methods have been developed and used in virtually all diseases to …

Steady-state analysis of an interleaved boost converter with coupled inductors

PW Lee, YS Lee, DKW Cheng… - IEEE transactions on …, 2000 - ieeexplore.ieee.org
Boost converters are widely used as power-factor corrected preregulators. In high-power
applications, interleaved operation of two or more boost converters has been proposed to …

Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model

M Kitazawa, D Cheng, MR Tsukamoto… - The Journal of …, 2011 - journals.aai.org
Inflammation is a key pathological hallmark of Alzheimer’s disease (AD), although its impact
on disease progression and neurodegeneration remains an area of active investigation. …

[PDF][PDF] Cas13d is a compact RNA-targeting type VI CRISPR effector positively modulated by a WYL-domain-containing accessory protein

…, H Zhang, KS Makarova, EV Koonin, DR Cheng… - Molecular cell, 2018 - cell.com
Bacterial class 2 CRISPR-Cas systems utilize a single RNA-guided protein effector to mitigate
viral infection. We aggregated genomic data from multiple sources and constructed an …

Functionally diverse type V CRISPR-Cas systems

…, S Chong, KS Makarova, EV Koonin, DR Cheng… - Science, 2019 - science.org
Type V CRISPR-Cas systems are distinguished by a single RNA-guided RuvC domain-containing
effector, Cas12. Although effectors of subtypes VA (Cas12a) and VB (Cas12b) have …

Differentiation and death of premyelinating oligodendrocytes in developing rodent brain

BD Trapp, A Nishiyama, D Cheng… - The Journal of cell …, 1997 - rupress.org
Previous studies have indicated that newly formed oligodendrocytes are dynamic cells whose
production, survival, and differentiation depend upon axonal influences. This study has …

Students' sense of campus community: What it means, and what to do about it

DX Cheng - NASPA journal, 2004 - Taylor & Francis
This study examines different aspects of students' collegelife to articulate their perceptions
of campus community.The findings indicate that students' sense of community is closely …

Thermoelastic stress in the semi‐infinite solid

RD Mindlin, DH Cheng - Journal of Applied Physics, 1950 - aip.scitation.org
The solution of the elasticity equations for the center of dilatation in the semi‐infinite solid is
introduced into Goodier's theory of thermoelastic stress. It is shown that the problem of …

Optimization techniques for antenna arrays

DK Cheng - Proceedings of the IEEE, 1971 - ieeexplore.ieee.org
Various techniques for optimizing the performance indices of antenna arrays are discussed.
In particular, methods for maximizing array directivity and signal-to-noise power ratio are …