Interfering with pH regulation in tumours as a therapeutic strategy

D Neri, CT Supuran - Nature reviews Drug discovery, 2011 - nature.com
The high metabolic rate of tumours often leads to acidosis and hypoxia in poorly perfused
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …

Targeting by affinity–matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform

D Neri, B Carnemolla, A Nissim, A Leprini… - Nature …, 1997 - nature.com
The oncofetal fibronectin (B-FN) isoform is present in vessels of neoplastic tissues during
angiogenesis but not in mature vessels. B-FN could therefore provide a target for diagnostic …

Tumour vascular targeting

D Neri, R Bicknell - Nature Reviews Cancer, 2005 - nature.com
It is now accepted that the growth of solid tumours is dependent on their capacity to acquire
a blood supply, and much effort has been directed towards the development of agents (…

Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by …

D Neri, T Szyperski, G Otting, H Senn, K Wuethrich - Biochemistry, 1989 - ACS Publications
Revised Manuscript Received July 11, 1989 abstract: Stereospecific* H and 13C NMR
assignments were made for the two diastereotopic methyl groups of the 14 valyl and leucyl …

A small‐molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors

…, GJL Bernardes, CT Supuran, D Neri - Angewandte Chemie …, 2014 - Wiley Online Library
… The research conducted by the Neri group on small-molecule-based tumor targeting is
funded by ETH Zurich, the Swiss National Science Foundation, and Oncosuisse. Prof. Dario Neri

NMR determination of residual structure in a urea-denatured protein, the 434-repressor

D Neri, M Billeter, G Wider, K Wüthrich - Science, 1992 - science.org
A nuclear magnetic resonance (NMR) structure determination is reported for the polypeptide
chain of a globular protein in strongly denaturing solution. Nuclear Overhauser effect (NOE) …

Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED‐B domain of fibronectin

…, J Sepulveda, O Burrone, D Neri… - … journal of cancer, 2002 - Wiley Online Library
We recently demonstrated that a human recombinant scFv, L19, reacting with the ED‐B
domain of fibronectin, a marker of angiogenesis, selectively targets tumoral vasculature in vivo. …

Antibody–drug conjugates: basic concepts, examples and future perspectives

G Casi, D Neri - Journal of controlled release, 2012 - Elsevier
Conventional anticancer therapeutics often suffer from lack of specificity, resulting in poor
therapeutic indexes and substantial toxicities to normal healthy tissues. Monoclonal antibodies …

Encoded self-assembling chemical libraries

S Melkko, J Scheuermann, CE Dumelin, D Neri - Nature biotechnology, 2004 - nature.com
The isolation of molecules capable of high-affinity and specific binding to biological targets is
a central problem in chemistry, biology and pharmaceutical sciences. Here we describe the …

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

…, E Rizzi, C Dumelin, S Melkko, D Neri - Proceedings of the …, 2008 - National Acad Sciences
DNA encoding facilitates the construction and screening of large chemical libraries. Here, we
describe general strategies for the stepwise coupling of coding DNA fragments to nascent …