Bcl‐2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase‐3 …

H Zhao, MA Yenari, D Cheng… - Journal of …, 2003 - Wiley Online Library
Bcl‐2 protects against both apoptotic and necrotic death induced by several cerebral insults.
We and others have previously demonstrated that defective herpes simplex virus vectors …

Rheumatoid factor as a potentiator of anti–citrullinated protein antibody–mediated inflammation in rheumatoid arthritis

…, LJ Lahey, CA Wagner, D Cheng… - Arthritis & …, 2014 - Wiley Online Library
Objective The co‐occurrence of rheumatoid factor (RF) and anti–citrullinated protein antibody
(ACPA) positivity in rheumatoid arthritis (RA) is well described. However, the mechanisms …

Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation

H Deng, HS Han, D Cheng, GH Sun, MA Yenari - Stroke, 2003 - Am Heart Assoc
Background and Purpose— We previously showed that mild hypothermia protects against
experimental stroke, even when cooling was delayed by 2 hours. Protection may be due in …

Effects of mild hypothermia on superoxide anion production, superoxide dismutase expression, and activity following transient focal cerebral ischemia

CM Maier, GH Sun, D Cheng, MA Yenari… - Neurobiology of …, 2002 - Elsevier
Following a transient ischemic insult there is a marked increase in free radical (FR) production
within the first 10–15 min of reperfusion and again at the peak of the inflammatory process…

Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions

…, MA Yenari, GH Sun, L Xu, MR Emond, D Cheng… - Experimental …, 2001 - Elsevier
We previously showed that overexpressing the 70-kDa inducible heat shock protein in primary
astrocyte cultures and in a rodent stroke model using viral vectors resulted in protection …

Local Joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis

…, T Gazitt, R Shiao, J Fert‐Bober, D Cheng… - Arthritis & …, 2015 - Wiley Online Library
Objective Anti–citrullinated protein antibodies (ACPAs) are characteristic of rheumatoid
arthritis (RA). However, their presence years before the onset of clinical RA is perplexing. …

Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia

Z Zhang, RA Sobel, D Cheng, GK Steinberg… - Molecular brain …, 2001 - Elsevier
Mild hypothermia protects the brain against experimental ischemia, but the reasons are not
well known. We examined whether the protective effects of mild hypothermia could be …

Mild Hypothermia Attenuates Cytochrome C Release but Does Not Alter Bcl-2 Expression or Caspase Activation after Experimental Stroke

MA Yenari, S Iwayama, D Cheng… - Journal of Cerebral …, 2002 - journals.sagepub.com
Mild hypothermia protects the brain from ischemia, but the underlying mechanisms of this
effect are not well known. The authors previously found that hypothermia reduces the density …

Bcl-2 Transfection via Herpes Simplex Virus Blocks Apoptosis-Inducing Factor Translocation after Focal Ischemia in the Rat

H Zhao, MA Yenari, D Cheng… - Journal of Cerebral …, 2004 - journals.sagepub.com
Apoptosis plays a critical role in many neurologic diseases, including stroke. Cytochrome c
release and activation of various caspases are known to occur after focal and global ischemia…

Glycogen synthase kinase 3β inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia

S Kelly, H Zhao, GH Sun, D Cheng, Y Qiao, J Luo… - Experimental …, 2004 - Elsevier
The serine/threonine kinase, glycogen synthase kinase 3β (GSK3β), is abundant in CNS
and is neuron specific. GSK3β plays a pivotal role in the regulation of numerous cellular …