Outcomes of observation vs stereotactic ablative radiation for oligometastatic prostate cancer: the ORIOLE phase 2 randomized clinical trial
…, S Dipasquale, TL DeWeese, DY Song… - JAMA …, 2020 - jamanetwork.com
Importance Complete metastatic ablation of oligometastatic prostate cancer may provide an
alternative to early initiation of androgen deprivation therapy (ADT). Objective To determine …
alternative to early initiation of androgen deprivation therapy (ADT). Objective To determine …
Pelvic radiation and normal tissue toxicity
Radiation is a component of treatment for many pelvic malignancies, most often originating
in the gynecologic, gastrointestinal, and genitourinary systems. Therefore, the management …
in the gynecologic, gastrointestinal, and genitourinary systems. Therefore, the management …
Radical prostatectomy, external beam radiotherapy, or external beam radiotherapy with brachytherapy boost and disease progression and mortality in patients with …
Importance The optimal treatment for Gleason score 9-10 prostate cancer is unknown. Objective
To compare clinical outcomes of patients with Gleason score 9-10 prostate cancer after …
To compare clinical outcomes of patients with Gleason score 9-10 prostate cancer after …
[HTML][HTML] Long-term outcomes and genetic predictors of response to metastasis-directed therapy versus observation in oligometastatic prostate cancer: analysis of …
…, G Villeirs, K De Man, F Ameye, DY Song… - Journal of clinical …, 2022 - ncbi.nlm.nih.gov
The use of metastasis-directed therapy (MDT) is rapidly increasing in the setting of oligometastasis.
STOMP and ORIOLE, the only two prospective trials of stereotactic ablative radiation …
STOMP and ORIOLE, the only two prospective trials of stereotactic ablative radiation …
[HTML][HTML] A phase II randomized trial of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr (ORIOLE)
Background We describe a randomized, non-blinded Phase II interventional study to assess
the safety and efficacy of stereotactic ablative radiotherapy (SABR) for hormone-sensitive …
the safety and efficacy of stereotactic ablative radiotherapy (SABR) for hormone-sensitive …
Efficacy of radium-223 in bone-metastatic castration-resistant prostate cancer with and without homologous repair gene defects
Background Pathogenic mutations in genes mediating homologous recombination (HR)
DNA repair are present in 20–30% of men with metastatic castrate-resistant prostate cancer (…
DNA repair are present in 20–30% of men with metastatic castrate-resistant prostate cancer (…
Combination of dual immune checkpoint inhibition (ICI) with stereotactic radiation (SBRT) in metastatic renal cell carcinoma (mRCC)(RADVAX RCC).
…, AM Laine, KD Courtney, J Brugarolas, DY Song… - 2020 - ascopubs.org
614 Background: Dual ICI with nivolumab/ipilimumab (N/I) has become a standard of care (SOC)
for patients (pts) with mRCC. Since the failure to respond to ICI may be due to a lack of …
for patients (pts) with mRCC. Since the failure to respond to ICI may be due to a lack of …
Scalp recorded spike ripples predict seizure risk in childhood epilepsy better than spikes
In the past decade, brief bursts of fast oscillations in the ripple range have been identified in
the scalp EEG as a promising non-invasive biomarker for epilepsy. However, investigation …
the scalp EEG as a promising non-invasive biomarker for epilepsy. However, investigation …
Development and validation of a clinical prognostic stage group system for nonmetastatic prostate cancer using disease-specific mortality results from the international …
Importance In 2016, the American Joint Committee on Cancer (AJCC) established criteria to
evaluate prediction models for staging. No localized prostate cancer models were endorsed …
evaluate prediction models for staging. No localized prostate cancer models were endorsed …
Metastasis-directed therapy prolongs efficacy of systemic therapy and improves clinical outcomes in oligoprogressive castration-resistant prostate cancer
Background Available therapies for castrate-resistant prostate cancer (CRPC) confer
minimal survival advantage; thus, there is interest in metastasis-directed therapy (MDT) for …
minimal survival advantage; thus, there is interest in metastasis-directed therapy (MDT) for …