We discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC)
in 11/45 (∼25%) primary CNS-PNET, which results in striking overexpression of …

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two
transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying …

Three histological variants are known within the family of embryonal rosette-forming
neuroepithelial brain tumors. These include embryonal tumor with abundant neuropil and true …

Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are
lethal childhood cancers with characteristic genetic alterations of SMARCB1/hSNF5. Lack of …

Background Childhood CNS primitive neuro-ectodermal brain tumours (PNETs) are very
aggressive brain tumours for which the molecular features and best treatment approaches are …

Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been
linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising …

Embryonal tumor with multilayered rosettes (ETMR, previously known as ETANTR) is a
highly aggressive embryonal CNS tumor, which almost exclusively affects infants and is …

Glioblastoma multiform (GBM) is the most common brain tumor characterized by a dismal
prognosis. GBM cancer stem cells (gCSC) or tumor-initiating cells are the cell population within …

Spatial heterogeneity of transcriptional and genetic markers between physically isolated
biopsies of a single tumor poses major barriers to the identification of biomarkers and the …

This report describes the prevalence of non‐cavitated and cavitated carious lesions in 911
randomly selected children in grades one through three on the Island of Montreal. Quebec, …