The pbuE adenine riboswitch undergoes metal ion-dependent folding that involves a loop-loop
interaction. Binding of 2-aminopurine to the aptamer domain strongly correlates with the …

Riboswitches are regulatory elements modulating gene expression in response to specific
metabolite binding. It has been recently reported that riboswitch agonists may exhibit …

Riboswitches are mRNA regulatory elements that control gene expression by altering their
structure in response to specific metabolite binding. In bacteria, riboswitches consist of an …

Many bacterial mRNAs are regulated at the transcriptional or translational level by ligand-binding
elements called riboswitches. Although they both bind adenine, the adenine …

Cryoplasty, a freezing therapy, is being used for the treatment of restenosis in peripheral
arteries. In addition, cryo-preserved arteries are increasingly used in vascular grafts. While …

Recent advances in prokaryote genetics have highlighted the important and complex roles
of small regulatory RNAs (sRNAs). Although blocking mRNA translation is often the main …

Clostridium difficile is an anaerobic Gram-positive bacterium that causes intestinal
infections with symptoms ranging from mild diarrhea to fulminant colitis. Cyclic diguanosine …

Therapeutic approaches employing RNA as a tool or as a drug target have recently emerged
and have been employed for various applications—ranging from cancer treatment to virus …

S-adenosylmethionine (SAM) riboswitches are widespread in bacteria, and up to five different
SAM riboswitch families have been reported, highlighting the relevance of SAM regulation. …

Guanine riboswitches negatively modulate transcription upon guanine binding. The aptamer
domain is organized around a three-way junction which forms the ligand binding site. Using …