User profiles for Daniel L.J. Thorek

Daniel LJ Thorek

Assistant Professor at Washington University School of Medicine
Verified email at wustl.edu
Cited by 6071

Superparamagnetic iron oxide nanoparticle probes for molecular imaging

DLJ Thorek, AK Chen, J Czupryna… - Annals of biomedical …, 2006 - Springer
The field of molecular imaging has recently seen rapid advances in the development of
novel contrast agents and the implementation of insightful approaches to monitor biological …

Concise review: mesenchymal stem cell-based drug delivery: the good, the bad, the ugly, and the promise

TEG Krueger, DLJ Thorek… - Stem cells …, 2018 - academic.oup.com
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …

Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells

DLJ Thorek, A Tsourkas - Biomaterials, 2008 - Elsevier
A promising new direction for contrast-enhanced magnetic resonance (MR) imaging
involves tracking the migration and biodistribution of superparamagnetic iron oxide (SPIO)-labeled …

Cerenkov imaging

S Das, DLJ Thorek, J Grimm - Advances in cancer research, 2014 - Elsevier
Cerenkov luminescence (CL) has been used recently in a plethora of medical applications
like imaging and therapy with clinically relevant medical isotopes. The range of medical …

Elective nodal irradiation attenuates the combinatorial efficacy of stereotactic radiation therapy and immunotherapy

…, KB Thudium, AJ Korman, D Ulmert, DLJ Thorek… - Clinical Cancer …, 2018 - AACR
Purpose: In the proper context, radiotherapy can promote antitumor immunity. It is unknown
if elective nodal irradiation (ENI), a strategy that irradiates tumor-associated draining lymph …

[HTML][HTML] Gd-conjugated dendrimer nanoclusters as a tumor-targeted T1 magnetic resonance imaging contrast agent

Z Cheng, DLJ Thorek, A Tsourkas - … Chemie (International ed. in …, 2010 - ncbi.nlm.nih.gov
Contrast agents are increasingly being used in diagnostic magnetic resonance (MR) imaging
to help detect and characterize pathological abnormalities. In fact, it has been estimated …

[HTML][HTML] Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle

DLJ Thorek, D Ulmert, NFM Diop, ME Lupu… - Nature …, 2014 - nature.com
The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer
stage and is important for treatment planning. Clinicians currently use planar scintigraphy and …

Quantitative imaging of disease signatures through radioactive decay signal conversion

DLJ Thorek, A Ogirala, BJ Beattie, J Grimm - Nature medicine, 2013 - nature.com
In the era of personalized medicine, there is an urgent need for in vivo techniques able to
sensitively detect and quantify molecular activities. Sensitive imaging of gamma rays is widely …

Clinical Cerenkov luminescence imaging of 18F-FDG

DLJ Thorek, CC Riedl, J Grimm - Journal of Nuclear Medicine, 2014 - Soc Nuclear Med
The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging
of patients undergoing diagnostic 18 F-FDG scans to detect nodal disease. Methods: …

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

…, JK Kim, MA Hussain, DLJ Thorek… - Proceedings of the …, 2017 - National Acad Sciences
Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that
antagonizes the profound osteoanabolic capacity of activated Wnt/β-catenin signaling, but serum …