An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …

Given the limited success of conventional treatments for veterans with posttraumatic stress
disorder (PTSD), investigations of alternative approaches are warranted. We examined the …

Purpose: To determine the precision and accuracy of hepatic fat‐fraction measured with a
chemical shift‐based MRI fat‐water separation method, using single‐voxel MR spectroscopy (…

Animal studies suggest that the apolipoprotein E ε4 (APOEε4) allele is a culprit of early
microglial activation in Alzheimer’s disease (AD). Here, we tested the association between …

Tracking longitudinal tau tangles accumulation across the Alzheimer’s disease continuum is
crucial to better understand the natural history of tau pathology and for clinical trials. …

Indices of functional connectivity in the default mode network (DMN) are promising neural
markers of treatment response in late-life depression. We examined the differences in DMN …

Background The biomarker model of Alzheimer's disease postulates a dynamic sequence
of amyloidosis, neurodegeneration, and cognitive decline as an individual progresses from …

Resting-state functional MRI (rs-fMRI) has emerged as a powerful tool for investigating brain
functional connectivity (FC). Research in recent years has focused on assessing the …

Objectives Generalized anxiety disorder (GAD) is one of the most prevalent mental disorders
in the elderly, but its functional neuroanatomy is not well understood. Given the role of …

Astrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer’s disease (AD)
patients. Here, we studied the associations of cerebrospinal fluid (CSF) glial fibrillary acidic …