Metaiodobenzylguanidine (MIBG) is structurally similar to the neurotransmitter norepinephrine
and specifically targets neuroendocrine cells including some neuroendocrine tumors. …

Neuroblastoma, which derives from neural crest, is the most common extracranial solid
cancer in childhood. The tumors express the norepinephrine (NE) transporters on their cell …

Effective treatments for malignant neuroendocrine tumors are under development. While
iodine-131 metaiodobenzylguanidine (131I-MIBG) radiotherapy has been used in the treatment …

As a rare kind of non-epithelial neuroendocrine neoplasms, paragangliomas (PGLs) exhibit
various clinical characteristics with excessive catecholamine secretion and have been a …

Objective Subcommittee on Survey of Nuclear Medicine Practice in Japan has performed a
nationwide survey of nuclear medicine practice every 5 years since 1982 to survey …

Objective To evaluate the long-term efficacy and safety of diflunisal in late-onset familial
amyloid polyneuropathy (FAP) in a Japanese endemic area. Methods Consecutive six FAP …

Purpose The purpose of our study was to evaluate the degree of radiotoxicity to lymphocytes
in thyroid cancer after iodine-131(I-131) therapy using γ-H2AX foci immunodetection. …

Purpose We retrospectively examined whether or not initial responses of first low-dose 131 I-meta-iodo-benzyl-guanidine
radiotherapy ( 131 I-MIBG therapy) in patients with malignant …

Objective In this phase II study, we aimed to investigate the efficacy and safety of single-dose
[ 131 I]meta-iodobenzylguanidine ( 131 I-mIBG) therapy in patients with refractory …

Objective The aim of the study was to investigate the outcomes and prognostic factors of
high-dose 131 I-metaiodobenzylguanidine ( 131 I-MIBG) therapy in patients with refractory or …