The rupture of atherosclerotic plaques and the subsequent formation of thrombi are the
main factors responsible for myocardial and cerebral infarctions. Thus, the detection of …

Large macrocyclic peptides can achieve surprisingly high membrane permeability, although
the properties that govern permeability in this chemical space are only beginning to come …

Lectin-like oxidized LDL receptor-1 (LOX-1), a cell-surface receptor for oxidized LDL (Ox-LDL),
has been implicated in vascular cell dysfunction related to atherosclerotic plaque …

Previously, based on the concept of bifunctional radiopharmaceuticals, we developed a
highly stable 186 Re-mercaptoacetylglycylglycylglycine (MAG3) complex–conjugated …

A highly potent, selective Na V 1.7 inhibitor, DS-1971a, has been discovered. Exploration of
the left-hand phenyl ring of sulfonamide derivatives (I and II) led to the discovery of novel …

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the
NAD + salvage pathway. Since NAD + plays a pivotal role in many biological processes …

To meet unmet medical needs, middle-to-large molecules, including peptides and
oligonucleotides, have emerged as new therapeutic modalities. Owing to their middle-to-large …

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the
nicotinamide adenine dinucleotide (NAD+) salvage pathway. Because NAD+ plays a pivotal …

Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by
out-of-frame or nonsense mutation in the dystrophin gene. It begins with a loss of ambulation …

Since elevated levels of gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] are
associated with a poor prognosis in cancer patients, these enzymes are potential targets for …