Avidin* and Streptavidin* were both conjugated with DTPA using the cyclic anhydride of
DPTA*(13). The proteins were prepared at a concentration of 20 mg/ml in 0.05 M bicarbonate …

A simple and efficient method of covalently coupling the strong chelator
diethylenetriaminepentaacetic acid to proteins was developed for radiolabeling immunoglobulin G …

A new method has been developed for the coupling of diethylenetriaminepentaacetic acid (DTPA)
to proteins using the cyclic anhydride of DTPA. The anhydride, prepared by a simple …

Isotopes of iodine are often employed as radiolabels for antibodies used in radioimmunodetection
studies in which tumor localization is determined by external imaging. Because of …

For radiotherapy, biomolecules such as intact antibodies, antibody fragments, peptides, DNAs
and other oligomers have all been labeled with radiorhenium (186Re and 188Re). Three …

This report describes preliminary results in a limited clinical trial of the pretargeting concept
in patients in which streptavidin and biotin have been employed be cause of the high affinity (…

The use of radiolabeled antibodies for tumor detection and therapy has provided some striking
successes despite unfavorable tumor-to-normal tissue radioactivity ratios due, in part, to …

The chemical modification of oligomers such as DNA, PNA, MORF, LNA to attach radionuclides
for nuclear imaging and radiotherapy applications has become a field rich in innovation …

Yttrium-90 has been described as one of the best radionuclides for tumor therapy when
chelated to tumor-associated antibodies. This evaluation is based on the superior properties of …

Over the past several years, investigators in this laboratory and elsewhere have been studying
tumor localization by pretargeting with streptavidin and biotin or with avidin and biotin. …