Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18) 2‐fluoro‐2‐deoxy‐D‐glucose: validation of method

…, C Selin, L Sokoloff, DE Kuhl - Annals of Neurology …, 1979 - Wiley Online Library
… This trapping mechanism provides an excellent means for development and application of
analytical models for the measurement of CMRGlc with PCT. Like DG, FDG has been shown …

Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease

…, S Berent, KA Frey, NL Foster, DE Kuhl - Annals of Neurology …, 1997 - Wiley Online Library
This study investigated cerebral glucose metabolism in very early Alzheimer's disease,
before a clinical diagnosis of probable Alzheimer's disease is possible, using [ 18 F]…

Noninvasive determination of local cerebral metabolic rate of glucose in man

…, K Sideris, CJ Selin, DE Kuhl - American Journal …, 1980 - journals.physiology.org
… phosphorylated DG is not a substrate for further metabolic reactions (3, 11, 34): the permeability
of cell membranes to the phosphorylated DG’ is low (36), and the reverse reaction of de

[PDF][PDF] A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET

…, KA Frey, RA Koeppe, NL Foster, DE Kuhl - Journal of Nuclear …, 1995 - Soc Nuclear Med
… Z-score for normalcontrols, a jackknife-typeprocedurewas used as de scribed in the next …
AlthOUghasymmetty in the de gree ofmetabolic reduction can exist (4,9,10,15,18—20),both …

Image separation radioisotope scanning

DE Kuhl, RQ Edwards - Radiology, 1963 - pubs.rsna.org
… is the failure of the detector system to resolve … de scrutinage currentemente in uso, le
imagines de omne nivellos del corpore se superimpone in le complete registration. Le imagine de

Labeled 2‐deoxy‐D‐glucose analogs. 18F‐labeled 2‐deoxy‐2‐fluoro‐D‐glucose, 2‐deoxy‐2‐fluoro‐D‐mannose and 14C‐2‐deoxy‐2‐fluoro‐D‐glucose

…, JS Fowler, AP Wolf, M Reivich, DE Kuhl - Journal of Labelled …, 1978 - Wiley Online Library
A convenient method for the synthesis of 18 F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and 18 F‐2‐deoxy‐2‐fluoro‐D‐mannose
(8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with …

Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging

…, J Krivokapich, H Schelbert, DE Kuhl - Journal of the American …, 1990 - Elsevier
… , represents the combined processes of ry of the ~dion~cl~de to the tissue by bl at-action of
the tracer across the capiil ce ma single capillary transit and must have units of tissue per min…

Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation

…, AAF Sima, KA Frey, RL Albin, DE Kuhl - Annals of Neurology …, 2001 - Wiley Online Library
Seeking antemortem markers to distinguish Dementia with Lewy bodies (DLB) and Alzheimer's
disease (AD), we examined brain glucose metabolism of DLB and AD. Eleven DLB …

N-13 ammonia as an indicator of myocardial blood flow.

…, NS MacDonald, H Hansen, C Selin, DE Kuhl - Circulation, 1981 - Am Heart Assoc
We have characterized N-13 ammonia as a myocardial blood flow imaging agent suitable
for positron-emission computed tomography. However, themechanisms of uptake and …

In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease

DE Kuhl, S Minoshima, JA Fessler… - Annals of Neurology …, 1996 - Wiley Online Library
… Instead, our data are more likely consistent with a cholinergic degenerative process in
which enzymatic activity fails prior to actual loss of terminals. Our scan measures of cholinergic …