Naltrexone fails to antagonize the σ effects of PCP and SKF 10,047 in the dog

DB Vaupel - European journal of pharmacology, 1983 - Elsevier
SKF 10,047, N-allylnormetazocine, a benzomorphan narcotic antagonist, and the
arylcyclohexylamine anesthetic phencyclidine produced similar reflex, autonomic and behavioral …

When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor

TP Su, T Hayashi, DB Vaupel - Science signaling, 2009 - science.org
N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is
commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine–…

Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380

…, CS Contoreggi, AG Horti, DB Vaupel… - Journal of Nuclear …, 2008 - Soc Nuclear Med
… had to have smoked at least 15 cigarettes/d for at least the last 2 consecutive years. …
Mukhin and D. Bruce Vaupel, unpublished data, 2005) showed practically no accumulation …

2 [18F]F‐A85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans

…, JA Matochik, O Pavlova, D Bruce Vaupel… - The FASEB …, 2003 - Wiley Online Library
Noninvasive imaging of nicotinic acetylcholine receptors (nAChRs) in the human brain in
vivo is critical for elucidating the role of these receptors in normal brain function and in the …

5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors

…, G Tamagnan, AS Kimes, J Chambers, DB Vaupel… - Molecular …, 2000 - ASPET
In an effort to develop selective radioligands for in vivo imaging of neuronal nicotinic
acetylcholine receptors (nAChRs), we synthesized 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine (5-…

Nitric oxide synthase inhibitors

DB Vaupel, AS Kimes, ED London - Neuropsychopharmacology, 1995 - nature.com
Four inhibitors of nitric oxide synthase (NOS), administered as acute pretreatments, attenuated
several signs of naloxone-precipitated opioid withdrawal in morphine-dependent rats. …

Comparison of 7-nitroindazole with other nitric oxide synthase inhibitors as attenuators of opioid withdrawal

D Bruce Vaupel, AS Kimes, ED London… - Psychopharmacology, 1995 - Springer
Previously, we demonstrated that two nonselective inhibitors of nitric oxide synthase (NOS),l-N
G -nitroarginine (l-NNA) andl-N G -nitroarginine methyl ester (l-NAME), reduced some …

Attenuation of some signs of opioid withdrawal by inhibitors of nitric oxide synthase

AS Kimes, DB Vaupel, ED London - Psychopharmacology, 1993 - Springer
Abstract Effects of nitric oxide synthase (NOS) inhibitors (l-N G -nitroarginine,l-N G -nitroarginine
methyl ester) on precipitated opioid withdrawal were studied in morphine-dependent …

Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F] F-A85380

…, SI Chefer, JA Matochik, CS Contoreggi, DB Vaupel… - Neuroimage, 2008 - Elsevier
Quantitative analysis of most positron emission tomography (PET) data requires arterial blood
sampling and dynamic scanning when the radioligand is administered as a bolus injection…

Abstinence from cocaine and sucrose self-administration reveals altered mesocorticolimbic circuit connectivity by resting state MRI

H Lu, Q Zou, S Chefer, TJ Ross, DB Vaupel… - Brain …, 2014 - liebertpub.com
Previous preclinical studies have emphasized that drugs of abuse, through actions within
and between mesocorticolimbic (MCL) regions, usurp learning and memory processes …