Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species–mediated hypoxia-inducible factor-1α activation
KH Jung, JH Lee, CHT Quach, JY Paik… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Resveratrol is gaining attention for its anticancer effects and is also recognized for its antioxidant
properties and influence on glucose metabolism. Augmented reactive oxygen species (…
properties and influence on glucose metabolism. Augmented reactive oxygen species (…
Resveratrol-loaded polymeric nanoparticles suppress glucose metabolism and tumor growth in vitro and in vivo
KH Jung, JH Lee, JW Park, CHT Quach… - International Journal of …, 2015 - Elsevier
Resveratrol (RSV) is a natural phenol with promising anti-tumor activities, but its use for in
vivo cancer treatment is limited by low aqueous solubility and poor stability. In this study, we …
vivo cancer treatment is limited by low aqueous solubility and poor stability. In this study, we …
Oxidized low-density lipoprotein stimulates macrophage 18F-FDG uptake via hypoxia-inducible factor-1α activation through Nox2-dependent reactive oxygen species …
SJ Lee, CHT Quach, KH Jung, JY Paik… - Journal of Nuclear …, 2014 - Soc Nuclear Med
For 18 F-FDG PET to be widely used to monitor atherosclerosis progression and therapeutic
response, it is crucial to better understand how macrophage glucose metabolism is …
response, it is crucial to better understand how macrophage glucose metabolism is …
18F-FDG PET/CT monitoring of β3 agonist–stimulated brown adipocyte recruitment in white adipose tissue
JW Park, KH Jung, JH Lee, CHT Quach… - Journal of Nuclear …, 2015 - Soc Nuclear Med
There is rising interest in recruitment of brown adipocytes into white adipose tissue (WAT)
as a means to augment energy expenditure for weight reduction. We thus investigated the …
as a means to augment energy expenditure for weight reduction. We thus investigated the …
[HTML][HTML] Mild alkalization acutely triggers the Warburg effect by enhancing hexokinase activity via voltage-dependent anion channel binding
CHT Quach, KH Jung, JH Lee, JW Park, SH Moon… - PloS one, 2016 - journals.plos.org
To fully understand the glycolytic behavior of cancer cells, it is important to recognize how it
is linked to pH dynamics. Here, we evaluated the acute effects of mild acidification and …
is linked to pH dynamics. Here, we evaluated the acute effects of mild acidification and …
EGF receptor targeted tumor imaging with biotin-PEG-EGF linked to 99mTc-HYNIC labeled avidin and streptavidin
KH Jung, JW Park, JY Paik, CHT Quach… - Nuclear medicine and …, 2012 - Elsevier
INTRODUCTION: As direct radiolabeled peptides suffer limitations for in vivo imaging, we
investigated the usefulness of radioloabeled avidin and streptavidin as cores to link peptide …
investigated the usefulness of radioloabeled avidin and streptavidin as cores to link peptide …
Quantification of early adipose-derived stem cell survival: comparison between sodium iodide symporter and enhanced green fluorescence protein imaging
CHT Quach, KH Jung, JY Paik, JW Park, EJ Lee… - Nuclear medicine and …, 2012 - Elsevier
OBJECTIVE: Strategies to overcome the problem of extensive early stem cell loss following
transplantation requires a method to quantitatively assess their efficacy. This study compared …
transplantation requires a method to quantitatively assess their efficacy. This study compared …
Annexin V imaging detects diabetes-accelerated apoptosis and monitors the efficacy of benfotiamine treatment in ischemic limbs of mice
…, JH Lee, JW Park, JY Paik, CHT Quach… - Molecular …, 2014 - journals.sagepub.com
The role of apoptosis imaging for monitoring treatment response in ischemic limbs has not
been properly explored. In this study, we investigated the ability of annexin V (AnxV) imaging …
been properly explored. In this study, we investigated the ability of annexin V (AnxV) imaging …
[HTML][HTML] Reporter PET images bortezomib treatment-mediated suppression of cancer cell proteasome activity
JH Lee, KH Jung, CHT Quach, JW Park, SH Moon… - Scientific Reports, 2018 - nature.com
Proteasomal protein degradation is a promising target for cancer therapy. Here, we developed
a positron emission tomography (PET) technique based on the sodium-iodide symporter (…
a positron emission tomography (PET) technique based on the sodium-iodide symporter (…
Troglitazone stimulates cancer cell uptake of 18F-FDG by suppressing mitochondrial respiration and augments sensitivity to glucose restriction
SH Moon, SJ Lee, KH Jung, CHT Quach… - Journal of Nuclear …, 2016 - Soc Nuclear Med
We evaluated how troglitazone influences cancer cell glucose metabolism and uptake of 18
F-FDG, and we investigated its molecular mechanism and relation to the drug’s anticancer …
F-FDG, and we investigated its molecular mechanism and relation to the drug’s anticancer …