Tumor cell adaptation to hypoxic stress is an important determinant of malignant progression.
While much emphasis has been placed on the role of HIF‐1 in this context, the role of …

Hypoxia profoundly influences tumor development and response to therapy. While progress
has been made in identifying individual gene products whose synthesis is altered under …

The transcription factor ATF4 regulates the expression of genes involved in amino acid
metabolism, redox homeostasis and ER stress responses, and it is overexpressed in human solid …

… We would like to thank all the members of the Koumenis lab for generating the data mentioned
here and our … Koumenis and a WFUSM Dean's graduate fellowship to Diane R. Fels. …

Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent
apoptosis in oncogenically transformed cells. Unlike DNA damage, hypoxia does not induce …

Melanomas that result from mutations in the gene encoding BRAF often become resistant to
BRAF inhibition (BRAFi), with multiple mechanisms contributing to resistance. While therapy-…

The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the
pathogenic state, c-Myc–induced apoptosis is bypassed via a critical, yet poorly understood …

Hypoxia has recently been shown to activate the endoplasmic reticulum kinase PERK,
leading to phosphorylation of eIF2α and inhibition of mRNA translation initiation. Using a …

To proliferate and expand in an environment with limited nutrients, cancer cells co-opt
cellular regulatory pathways that facilitate adaptation and thereby maintain tumor growth and …

Poor oxygenation (hypoxia) is present in the majority of human tumors and is associated with
poor prognosis due to the protection it affords to radiotherapy and chemotherapy. Hypoxia …