The blood–brain barrier (BBB) consists of specific physical barriers, enzymes and transporters,
which together maintain the necessary extracellular environment of the central nervous …

Angiogenesis, the process by which new blood vessels arise from preexisting ones, is critical
for embryonic development and is an integral part of many disease processes. Recent …

Lack of robust methods for establishment and expansion of pluripotent human embryonic stem
(hES) cells still hampers development of cell therapy. Laminins (LN) are a family of highly …

For decades, DNA has been considered as the main cellular target of deleterious effects of
ionizing radiation (IR). Nevertheless, molecular signals initiated at cellular membranes are …

Establishing effective central tolerance requires the promiscuous expression of tissue-restricted
antigens by medullary thymic epithelial cells. However, whether central tolerance also …

Vascular development of the central nervous system and blood-brain barrier (BBB) induction
are closely linked processes. The role of factors that promote endothelial sprouting and …

A previous in vitro study showed that sphingosine-1-phosphate (S1P), a ceramide antagonist,
preserved endothelial cells in culture from radiation-induced apoptosis. We proposed to …

Formation and homeostasis of the vascular system requires several coordinated cellular
functions, but their precise interplay during development and their relative importance for …

The p38 MAPK signaling pathway is essential in the cellular response to stress stimuli, in
particular in the endothelial cells that are major target of external stress. The importance of the …

Because of the central role of the endothelium in tissue homeostasis, protecting the vasculature
from radiation-induced death is a major concern in tissue radioprotection. Premitotic …