In a prospective phase I/II clinical study, we treated eight patients suffering from recurrent
glioblastoma multiform with stereotactically guided intratumoral convection‐enhanced delivery …

Because of the high glucose metabolism in normal brain tissue 18 F-FDG is not the ideal
tracer for the detection of gliomas. Methyl- 11 C-l-methionine ( 11 C-MET) is better suited for …

To further develop gene therapy for patients with glioblastomas, an experimental gene therapy
protocol was established comprising a series of imaging parameters for (i) noninvasive …

For the development of efficient and safe gene therapy protocols for clinical application it is
desirable to determine the tissue dose of vector-mediated therapeutic gene expression …

For the purpose of implementing steam sterilization of 2-[ 18 F]FDG (FDG) in the final container
into routine production, we have validated and established a fully automated dispensing …

To develop efficient and safe gene therapy approaches, the herpes simplex virus type 1
thymidine kinase gene (HSV-1-tk) has been shown to function as a marker gene for the direct …

Over 10 years ago, the first successful gene therapy paradigms for experimental brain
tumors models have been conducted, and they were thought to revolutionize the treatment of …

Molecular imaging aims towards the non‐invasive kinetic and quantitative assessment and
localization of biological processes of normal and diseased cells in vivo in animal models …

A phase I/II clinical trial of gene therapy for recurrent glioblastoma has been initiated in
which non-invasive monitoring of the critical steps is performed by a combination of standard …

The important rote of nitric oxide (NO) as mediator of various regulating processes induding
vasorelaxation, neurotransmission and cytotoxity has Ied to a growing interest in radio-…