2-Deoxy-2- 18 F-fluoro-d-glucose (2-FDG) with PET is undeniably useful in the clinic, being
able, among other uses, to monitor change over time using the 2-FDG SUV metric. This …

Review of: The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF)
locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct …

The diagnostic definition of indeterminate lung nodules as malignant or benign poses a major
challenge for clinicians. We discovered a potential marker, the sodium-dependent glucose …

Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly
imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate the …

A key strategy to achieve regulated gene expression in higher eukaryotes is to prevent
illegitimate signal-independent activation by imposing robust control on the dismissal of …

Transcriptional activation of the cyclin D1 gene (CCND1) plays a pivotal role in G 1 -phase
progression, which is thereby controlled by multiple regulatory factors, including nuclear …

Epigenetic adaptation allows cancer cells to overcome the tumor-suppressive effects of glucose
restriction by inducing dedifferentiation and an aggressive phenotype, which could help …

Simple Summary Cancer cells change their metabolism to support a chaotic and
uncontrolled growth. In addition to meeting the metabolic needs of the cell, these changes in …

A novel glucose transporter, the sodium glucose cotransporter 2 (SGLT2), has been
demonstrated to contribute to the demand for glucose by pancreatic and prostate tumors, and its …

Kidneys contribute to glucose homeostasis by reabsorbing filtered glucose in the proximal
tubules via sodium-glucose cotransporters (SGLTs). Reabsorption is primarily handled by …