High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However,
no data are available on the relationship between IL-6 and mammary stem/progenitor cells, …

We have investigated the importance of interleukin-6 (IL-6) in promoting tumor growth and
metastasis. In human primary breast cancers, increased levels of IL-6 were found at the tumor …

We previously obtained evidence for reduced cell proliferation in the dentate gyrus (DG) of
fetuses with Down syndrome (DS), suggesting that the hippocampal hypoplasia seen in …

Routine sections of normal and pathological samples fixed in 10 per cent buffered formalin
or B5, including EDTA‐decalcified bone‐marrow biopsies, were tested with 61 antibodies …

Background: The purpose of this phase II study was to evaluate the efficacy and safety of
cetuximab combined with FOLFIRI as a first-line treatment of advanced gastric or …

Down syndrome (DS), the leading genetic cause of mental retardation, is characterized by
reduced number of cortical neurons and brain size. The occurrence of these defects starting …

The comprehension of the basic biology of stem cells is expected to provide a useful insight
into the pathogenesis of cancer. In particular, there is evidence that hypoxia promotes stem …

Extracellular and intracellular mediators of inflammation, such as tumor necrosis factor
alpha (TNFα) and NF‐kappaB (NF‐κB), play major roles in breast cancer pathogenesis, …

Ovarian carcinomas represent a heterogeneous group of neoplasms consisting of separate
entities with distinct risk factors, precursor lesions, pathogenesis, patterns of spread, …

Despite the fact that several studies have been published regarding the prognostic factors
of neuroendocrine tumors (NETs), there are some cases in which available data are not …