Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

…, S Deeley, H Iwamuro, JP Lefaucheur, C Thiriez… - The Lancet, 2014 - thelancet.com
Background Parkinson's disease is typically treated with oral dopamine replacement therapies;
however, long-term treatment leads to motor complications and, occasionally, impulse …

Trial of Lixisenatide in Early Parkinson's Disease

…, SRW Stott, C Thalamas, C Thiriez… - … England Journal of …, 2024 - Mass Medical Soc
Background Lixisenatide, a glucagon-like peptide-1 receptor agonist used for the treatment
of diabetes, has shown neuroprotective properties in a mouse model of Parkinson’s disease. …

Increased microglial activation in patients with Parkinson disease using [18F]-DPA714 TSPO PET imaging

…, J Lagarde, M Sarazin, P Hantraye, C Thiriez… - Parkinsonism & related …, 2021 - Elsevier
Introduction Increasing evidence suggests that neuroinflammation is active in Parkinson
disease (PD) and contributes to neurodegeneration. This process can be studied in vivo with …

Optimized quantification of translocator protein radioligand 18F-DPA-714 uptake in the brain of genotyped healthy volunteers

…, MA Peyronneau, B Bodini, C Thiriez… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Translocator protein (TSPO) is expressed at a low level in healthy brain and is upregulated
during inflammatory processes that may occur in neurodegenerative diseases. Thus, TSPO …

A French survey on the lockdown consequences of COVID-19 pandemic in Parkinson's disease. The ERCOPARK study

…, V Rousseau, A Sommet, C Thalamas, C Thiriez… - Parkinsonism & Related …, 2021 - Elsevier
Background In 2020 the coronavirus disease 19 (COVID-19) pandemic imposed a total and
sudden lockdown. We aimed to investigate the consequences of the first COVID-19 …

Can nicotine be used medicinally in Parkinson's disease?

C Thiriez, G Villafane, F Grapin, G Fenelon… - Expert review of …, 2011 - Taylor & Francis
The risk of Parkinson’s disease is reduced by cigarette smoking, which raises some
unanswered questions. Nicotine, a major component of tobacco smoke, could exert either …

[HTML][HTML] Spinal stimulation for movement disorders

C Thiriez, JM Gurruchaga, C Goujon, G Fénelon… - …, 2014 - Elsevier
Epidural spinal cord stimulation (SCS) is currently proposed to treat intractable neuropathic
pain. Since the 1970s, isolated cases and small cohorts of patients suffering from dystonia, …

Using the accelerometers integrated in smartphones to evaluate essential tremor

S Senova, D Querlioz, C Thiriez, P Jedynak… - Stereotactic and …, 2015 - karger.com
Background/Aims: Evaluation of tremor constitutes a crucial step from the diagnosis to the
initial treatment and follow-up of patients with essential tremor. The severity of tremor can be …

A Double‐Blind, Randomized, Placebo‐Controlled Trial of Bumetanide in Parkinson's Disease

…, JL Houeto, S Le Dily, M Mongin, C Thiriez… - Movement …, 2024 - Wiley Online Library
Background Acting on the main target of dopaminergic cells, the striatal γ‐aminobutyric acid
(GABA)‐ergic cells, might be a new way to treat persons with Parkinson's disease (PD). …

Amantadine use in the French prospective NS-Park cohort

…, M Tir, M Bereau, WG Meissner, C Thiriez… - Journal of Neural …, 2024 - Springer
Objective To assess amantadine use and associated factors in the patients with Parkinson’s
disease (PD). Background Immediate-release amantadine is approved for the treatment of …