[HTML][HTML] Automated quantitative gait analysis in animal models of movement disorders
C Vandeputte, JM Taymans, C Casteels, F Coun, Y Ni… - BMC neuroscience, 2010 - Springer
Background Accurate and reproducible behavioral tests in animal models are of major
importance in the development and evaluation of new therapies for central nervous system …
importance in the development and evaluation of new therapies for central nervous system …
Role of the GLUT1 glucose transporter in postnatal CNS angiogenesis and blood-brain barrier integrity
…, R Ardicoglu, J Schaffenrath, C Casteels… - Circulation …, 2020 - Am Heart Assoc
Rationale: Endothelial cells (ECs) are highly glycolytic and generate the majority of their
energy via the breakdown of glucose to lactate. At the same time, a main role of ECs is to allow …
energy via the breakdown of glucose to lactate. At the same time, a main role of ECs is to allow …
[HTML][HTML] Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau …
…, P Baatsen, T Oyelami, N Pierrot, C Casteels… - Acta …, 2015 - Springer
Prion-like seeding and propagation of Tau-pathology have been demonstrated experimentally
and may underlie the stereotyped progression of neurodegenerative Tauopathies. …
and may underlie the stereotyped progression of neurodegenerative Tauopathies. …
Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [18F] MK-9470 PET
The endocannabinoid system (ECS) is implicated as a regulator of homeostasis of several
cerebral functions and is a novel target for drug treatment of neuropyschiatric disorders. So far…
cerebral functions and is a novel target for drug treatment of neuropyschiatric disorders. So far…
Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo
K Van Laere, C Casteels, I Dhollander… - Journal of Nuclear …, 2010 - Soc Nuclear Med
The type 1 cannabinoid receptor (CB1) is a crucial modulator of synaptic transmission in the
brain. Animal and postmortem human data suggest that mutant huntingtin represses CB1 …
brain. Animal and postmortem human data suggest that mutant huntingtin represses CB1 …
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral …
A Van der Perren, J Toelen, C Casteels, F Macchi… - Neurobiology of …, 2015 - Elsevier
Testing of new therapeutic strategies for Parkinson's disease (PD) is currently hampered by
the lack of relevant and reproducible animal models. Here, we developed a robust rat model …
the lack of relevant and reproducible animal models. Here, we developed a robust rat model …
Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain
C Casteels, P Vermaelen, J Nuyts… - Journal of nuclear …, 2006 - Soc Nuclear Med
Automated voxel-based or predefined volume-of-interest (VOI) analysis of rodent small-animal
PET data is necessary for optimal use of information because the number of available …
PET data is necessary for optimal use of information because the number of available …
Changes in cerebral CB1 receptor availability after acute and chronic alcohol abuse and monitored abstinence
…, T Hompes, A Verhaeghen, C Casteels… - Journal of …, 2014 - Soc Neuroscience
Involvement of the type 1 cannabinoid receptor (CB 1 R) in the effects of alcohol on the brain
is supported by animal experiments, but how in vivo CB 1 R levels are altered in alcoholic …
is supported by animal experiments, but how in vivo CB 1 R levels are altered in alcoholic …
Towards a neurocircuitry in anorexia nervosa: evidence from functional neuroimaging studies
…, N Gérard, K Van Laere, C Casteels… - Journal of psychiatric …, 2009 - Elsevier
Functional neuroimaging is widely used to unravel changes in brain functioning in
psychiatric disorders. In the current study, we review single-photon emission tomography (SPECT), …
psychiatric disorders. In the current study, we review single-photon emission tomography (SPECT), …
Regional changes in type 1 cannabinoid receptor availability in Parkinson's disease in vivo
K Van Laere, C Casteels, S Lunskens, K Goffin… - Neurobiology of …, 2012 - Elsevier
The type 1 cannabinoid receptor (CB1) is a crucial modulator of synaptic transmission in
brain and has been proposed as a potential therapeutic target in Parkinson's disease (PD), …
brain and has been proposed as a potential therapeutic target in Parkinson's disease (PD), …