METHOD The study sample comprised 10 male chronic cocaine abusers (mean±SD age,
26.7±3.5 years; weight, 182±29 lb) who met the DSM-III-R diagnostic critena for cocaine abuse…

METHOD The subjects were 10 male schizophrenic inpatients aged 18 to 49 years who met
the DSM-III criteria and Research Diagnostic Criteria for chronic schizophrenia with either …

There is a great deal of clinical and experimental interest in determining tissue hypoxia
using non-invasive imaging methods. We have developed EF5, 2-(2-nitro-1[H]-imidazol-1-yl)-N-(2…

Recent advances in biomarkers provide the possibility of early or preclinical diagnosis of
Alzheimer’s pathology. Currently, decreased levels of Aβ-42 and increased levels of tau …

The purpose of this study was to develop a radiopharmaceutical that could be used to selectively
image 5‐HT 1A receptors with positron emission tomography (PET) No‐carrier‐added 4…

Background Leucine‐rich repeat kinase 2 (LRRK2) is a common risk gene for Parkinson's
disease (PD) and inflammatory bowel disorders. However, the penetrance of the most …

Background: Neuritic plaques and neurofibrillary tangles are the pathological hallmarks of
Alzheimer’s disease (AD), while the role of brain amyloid deposition in the clinical …

The noninvasive assessment of tumor hypoxia in vivo is under active investigationbecause
hypoxia has been shown to be an importantprognosticfactorfortherapyresistance. …

A new improved synthesis of 2-deoxy-2-(/sup 18/F)fluoro-D-glucose (2-/sup 18/FDG, 4) from
/sup 18/F-labeled acetyl hypofluorite (1) is described. Reaction of 3,4,6-tri-O-acetyl-D-glucal …

Background: Alterations in the brain serotonin (5-HT) system have been found in patients
with depression. We used the selective 5-HT transporter site ligand [ 11 C](+)McN5652 and …