The major function of vascular smooth muscle cells (SMCs) is contraction to regulate blood
pressure and flow. SMC contractile force requires cyclic interactions between SMC α-actin (…

Importance Patterns-of-failure studies suggest that in metastatic non–small-cell lung cancer (NSCLC)
sites of gross disease at presentation are the first to progress when treated with …

Importance Discontinuing aspirin after short-term dual antiplatelet therapy (DAPT) was
evaluated as a bleeding reduction strategy. However, the strategy of ticagrelor monotherapy has …

Background Obesity and type 2 diabetes are well-known risk factors for the development of
nonalcoholic fatty liver disease (NAFLD). However, NAFLD is not rare in nonobese, …

Our data showed that CAD, PAD, and ABI were more prevalent in men than in women aged
≥62 years. Of our 1,886 patients, only 705 (37%) had no CAD, PAD, or ABI. CAD was …

Roberts1 has suggested that aortic cuspal calcium is a form of atherosclerosis. Older persons
with valvular aortic stenosis (AS) have a higher prevalence of coronary risk factors, 2–5 a …

Serious complications have occurred in a considerable proportion of living donors of liver
transplants, but data from a single high‐volume center has rarely been available. We analyzed …

Objective Recent studies have suggested increased cardiovascular disease among patients
with rheumatoid arthritis (RA). We undertook this study to obtain morphologic evidence of …

Background/purpose Both curative resection and minimized in‐hospital mortality offer the
only chance of long‐term survival in patients with hilar cholangiocarcinoma. The reported …

Background Drug combinations rather than increasing doses of one drug can achieve
greater efficacy and lower risks. Thus, as an alternative to high-intensity statin monotherapy, …