Objective: To develop and validate a new standardized confusion assessment method (CAM)
that enables nonpsychiatric clinicians to detect delirium quickly in high-risk settings. Design…

The majority of putative disease-modifying treatments in development for Alzheimer’s
disease are directed against the amyloid-β (Aβ) peptide. Among the anti-Aβ therapeutic …

Background Mild cognitive impairment is a transitional state between the cognitive changes
of normal aging and early Alzheimer's disease. Methods In a double-blind study, we …

The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic
transmission is associated with this illness, but direct observation of abnormalities of dopamine …

Background The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may
initiate or potentiate pathologic processes in Alzheimer’s disease. Lecanemab, a humanized …

ContextSeveral reports from small clinical trials have suggested that estrogen replacement
therapy may be useful for the treatment of Alzheimer disease (AD) in women.ObjectiveTo …

Background Mild cognitive impairment (MCI) represents a transitional state between the
cognitive changes of normal aging and very early dementia and is becoming increasingly …

OBJECTIVE: The authors previously observed an increase in striatal dopamine transmission
following amphetamine challenge in 15 untreated patients with schizophrenia compared to …

Background Trials of monoclonal antibodies that target various forms of amyloid at different
stages of Alzheimer’s disease have had mixed results. Methods We tested solanezumab, …

Context Docosahexaenoic acid (DHA) is the most abundant long-chain polyunsaturated fatty
acid in the brain. Epidemiological studies suggest that consumption of DHA is associated …