Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers,
but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor …

10.7554/eLife.08347.001 Dengue and chikungunya are increasing global public health
concerns due to their rapid geographical spread and increasing disease burden. Knowledge of …

<p id="p001">The abscopal effect is a phenomenon in which local radiotherapy is associated
with the regression of metastatic cancer at a distance from the irradiated site. The abscopal …

Ronald Ross and George Macdonald are credited with developing a mathematical model of
mosquito-borne pathogen transmission. A systematic historical review suggests that several …

We report the development and isolation of a cell line, termed HepAD38, that replicates
human hepatitis B virus (HBV) under conditions that can be regulated with tetracycline. In the …

As the most common human cancer worldwide and continuing to increase in incidence,
basal cell carcinoma is associated with significant morbidity and cost. Continued advances in …

Over the past few years, the NCCN Guidelines for Melanoma: Cutaneous have been expanded
to include pathways for treatment of microscopic satellitosis (added in v2. 2020), and the …

Mathematical models of mosquito-borne pathogen transmission originated in the early twentieth
century to provide insights into how to most effectively combat malaria. The foundations …

Purpose Ipilimumab (Ipi), a monoclonal antibody against cytotoxic T-lymphocyte antigen-4,
has been shown to improve survival in patients with metastatic melanoma. In this single-…

Aedes aegypti and Ae. albopictus are the main vectors transmitting dengue and chikungunya
viruses. Despite being pathogens of global public health importance, knowledge of their …