Purpose A molecular target involved in the angiogenic process is the α v β 3 integrin. It has
been demonstrated in preclinical as well as in clinical studies that radiolabelled RGD …

T cells are key players in inflammation, autoimmune diseases, and immunotherapy. Thus,
holistic and noninvasive in vivo characterizations of the temporal distribution and homing …

Radioligand theranostics (RT) in oncology use cancer-type specific biomarkers and molecular
imaging (MI), including positron emission tomography (PET), single-photon emission …

Although T cells can be labeled for noninvasive in vivo imaging, little is known about the
impact of such labeling on T-cell function, and most imaging methods do not provide holistic …

Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterised by their
potential to control T-cell responses and to dampen inflammation. While the role of MDSCs in …

Monitoring the pharmacodynamic activity of cancer immunotherapy with novel molecular
imaging tools such as 89 Zr-Df-IAB22M2C for PET imaging is of prime importance to identify …

Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells of the myeloid
compartment and major players in the tumor microenvironment (TME). With increasing numbers …

Many pathophysiological processes are associated with proliferation, migration or death of
distinct cell populations. Monitoring specific cell types and their progeny in a non-invasive, …

We recently reported that miR-146a is differentially expressed in ALK+ and ALK− anaplastic
large cell lymphoma (ALCL). In this study, the downstream targets of miR-146a in ALK+ …

CD4+ T helper cells are capable of mediating long-term antitumoral immune responses. We
developed a combined immunotherapy (COMBO) using tumor antigen-specific T helper 1 …