User profiles for Christoph Handschin

Christoph Handschin

University of Basel, Biozentrum
Verified email at unibas.ch
Cited by 25391

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

S Jäger, C Handschin, J St.-Pierre… - Proceedings of the …, 2007 - National Acad Sciences
Activation of AMP-activated kinase (AMPK) in skeletal muscle increases glucose uptake,
fatty acid oxidation, and mitochondrial biogenesis by increasing gene expression in these …

[PDF][PDF] Metabolic control through the PGC-1 family of transcription coactivators

J Lin, C Handschin, BM Spiegelman - Cell metabolism, 2005 - cell.com
Many complex biological programs are controlled at the level of gene transcription by DNA
binding transcription factors. Recent studies have revealed a novel mode of regulation by …

[HTML][HTML] Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

…, M Uldry, JM Silvaggi, J Rhee, S Jäger, C Handschin… - Cell, 2006 - cell.com
PPARγ coactivator 1α (PGC-1α) is a potent stimulator of mitochondrial biogenesis and
respiration. Since the mitochondrial electron transport chain is the main producer of reactive …

The role of exercise and PGC1α in inflammation and chronic disease

C Handschin, BM Spiegelman - Nature, 2008 - nature.com
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie
muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently …

Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism

C Handschin, BM Spiegelman - Endocrine reviews, 2006 - academic.oup.com
Many biological programs are regulated at the transcriptional level. This is generally achieved
by the concerted actions of several transcription factors. Recent findings have shown that, …

PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

M Sandri, J Lin, C Handschin, W Yang… - Proceedings of the …, 2006 - National Acad Sciences
Maintaining muscle size and fiber composition requires contractile activity. Increased activity
stimulates expression of the transcriptional coactivator PGC-1α (peroxisome proliferator-…

An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle

C Handschin, J Rhee, J Lin, PT Tarr… - Proceedings of the …, 2003 - National Acad Sciences
Skeletal muscle adapts to chronic physical activity by inducing mitochondrial biogenesis and
switching proportions of muscle fibers from type II to type I. Several major factors involved in …

[HTML][HTML] Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP

J Lin, R Yang, PT Tarr, PH Wu, C Handschin, S Li… - Cell, 2005 - cell.com
The PGC-1 family of coactivators stimulates the activity of certain transcription factors and
nuclear receptors. Transcription factors in the sterol responsive element binding protein (…

Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

VK Mootha, C Handschin, D Arlow… - Proceedings of the …, 2004 - National Acad Sciences
Recent studies have shown that genes involved in oxidative phosphorylation (OXPHOS)
exhibit reduced expression in skeletal muscle of diabetic and prediabetic humans. Moreover, …

[PDF][PDF] Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

Z Arany, H He, J Lin, K Hoyer, C Handschin, O Toka… - Cell metabolism, 2005 - cell.com
Skeletal and cardiac muscle depend on high turnover of ATP made by mitochondria in order
to contract efficiently. The transcriptional coactivator PGC-1α has been shown to function as …