PET with selective adenosine 2A receptor (A 2A ) radiotracers can be used to study a
variety of neurodegenerative and neuropsychiatric disorders in vivo and to support drug-discovery …

Motor symptoms in Parkinson disease (PD) are caused by a loss of dopamine input from the
substantia nigra to the striatum. Blockade of adenosine 2A (A 2A ) receptors facilitates …

‘Click’ glycosylation of cysteine-containing peptides were carried out in good yield by
Copper(I)-catalyzed Azide–Alkyne Cycloaddition (CuAAC). For that peptides were functionalized …

Imaging agents that target adenosine type 2A (A 2A ) receptors play an important role in
evaluating new pharmaceuticals targeting these receptors, such as those currently being …

Neoglycopeptides are readily prepared by direct functionalization of cysteine-containing
peptides followed by click triazole formation between the resulting propargylated peptides …

An efficient synthetic strategy able to modulate the structure of the tetrahydropyridine isoindolone
(Valmerin) skeleton was developed. A library of more than 30 novel final structures was …

In vivo imaging of adenosine 2A receptors (A 2A ) in the brain has attracted significant interest
from the scientific community, because studies have shown that dysregulation of these …

Methods Two adult male monkeys (Macaca fascicularis) and three adult female baboons (Papio
anubis) were anesthetized and imaged on Neurofocus SPECT cameras. Baboons …

Polynitrogen heterocycles are often subject to Dimroth rearrangement which consists of ring
opening, bond rotation, and ring closure. In this note, we report a synthesis of two new …

Background To date, no studies are available comparing in-person versus telephone-administered
medication therapy management (MTM) encounters in a community pharmacy …