The ability to concentrate iodide is a fundamental property of normally functioning thyroid
tissue and represents the first step in the production of thyroid hormones. Iodide uptake has …

The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in …

Causing prostate cancer cells to express functionally active sodium iodide symporter (NIS)
by targeted NIS gene transfer might offer the possibility of radioiodine therapy of prostate …

Currently, no curative therapy for metastatic prostate cancer exists. Causing prostate cancer
cells to express functionally active sodium iodide symporter (NIS) would enable those cells …

Active transport of iodide into the thyroid gland is a crucial and rate-limiting step in the
biosynthesis of thyroid hormones that play an important role in the metabolism, growth, and …

Background— Prolonged myocardial ischemia results in cardiomyocyte loss despite successful
revascularization. We have reported that retrograde application of embryonic endothelial …

The sodium iodide symporter (NIS) is responsible for thyroidal, salivary, gastric, intestinal and
mammary iodide uptake. It was first cloned from the rat in 1996 and shortly thereafter from …

Iodineis an essential component of the thyroid hormones triiodothyronine (T3) and thyroxine
(T4), which play an im¬ portant role in the metabolism, growth and maturation of a variety of …

The human sodium iodide symporter (hNIS) is an intrinsic transmembrane protein that mediates
the active transport of iodide across the basolateral membrane of thyroid follicular cells. …

Approximately 30% of patients with advanced, metastatic differentiated thyroid cancer have
radioiodine-refractory disease, based on decreased expression of the sodium iodide …