Imaging robust microglial activation after lipopolysaccharide administration in humans with PET
CM Sandiego, JD Gallezot, B Pittman… - Proceedings of the …, 2015 - National Acad Sciences
Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric
diseases. The core process in neuroinflammation is activation of microglia, the innate …
diseases. The core process in neuroinflammation is activation of microglia, the innate …
[HTML][HTML] The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases
…, P Svenningsson, M Andréasson, C Sandiego… - Nature …, 2023 - nature.com
A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve
the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show …
the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show …
[HTML][HTML] Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET study
…, J Lampa, N Nabulsi, B Pittman, CM Sandiego… - European journal of …, 2019 - Springer
Purpose The purpose of this study was to investigate the effects of ageing, sex and body
mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron …
mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron …
Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers
…, VM Carroll, L Mistico, D Alagille, CM Sandiego… - Molecular Imaging and …, 2019 - Springer
Purpose Synaptic vesicle protein 2A (SV2A) serves as a biomarker of synaptic density and
positron emission tomography (PET) imaging of SV2A could provide a tool to assess …
positron emission tomography (PET) imaging of SV2A could provide a tool to assess …
Reference Region Modeling Approaches for Amphetamine Challenge Studies with [11C]FLB 457 and PET
CM Sandiego, JD Gallezot, K Lim… - Journal of Cerebral …, 2015 - journals.sagepub.com
Detecting fluctuations in synaptic dopamine levels in extrastriatal brain regions with [ 11 C]FLB
457 and positron emission tomography (PET) is a valuable tool for studying …
457 and positron emission tomography (PET) is a valuable tool for studying …
Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum
KP Cosgrove, MG Veldhuizen, CM Sandiego… - Synapse, 2015 - Wiley Online Library
Findings from clinical and preclinical studies converge to suggest that increased adiposity
and/or exposure to a high fat diet are associated with alterations in dorsal striatal (DS) circuitry…
and/or exposure to a high fat diet are associated with alterations in dorsal striatal (DS) circuitry…
[HTML][HTML] Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal …
…, M DeTure, D Russell, BA Navia, C Sandiego… - Acta Neuropathologica …, 2023 - Springer
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are distinct
clinicopathological subtypes of frontotemporal lobar degeneration. They both have atypical …
clinicopathological subtypes of frontotemporal lobar degeneration. They both have atypical …
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
…, S Nag, L Orsatti, C Sandiego… - Journal of Medicinal …, 2022 - ACS Publications
Therapeutic interventions are being developed for Huntington’s disease (HD), a hallmark of
which is mutant huntingtin protein (mHTT) aggregates. Following the advancement to …
which is mutant huntingtin protein (mHTT) aggregates. Following the advancement to …
Evaluation of [11C] MRB for assessment of occupancy of norepinephrine transporters: studies with atomoxetine in non-human primates
[ 11 C]MRB is one of the most promising radioligands used to measure brain norepinephrine
transporters (NET) with positron emission tomography (PET). The objective of this study …
transporters (NET) with positron emission tomography (PET). The objective of this study …
Evaluation of dosimetry, quantitative methods, and test–retest variability of 18F-PI-2620 PET for the assessment of tau deposits in the human brain
…, O Barret, C Constantinescu, C Sandiego… - Journal of Nuclear …, 2020 - Soc Nuclear Med
18 F-PI-2620 is a next-generation tau PET tracer that has demonstrated ability to image the
spatial distribution of suspected tau pathology. The objective of this study was to assess the …
spatial distribution of suspected tau pathology. The objective of this study was to assess the …