Arginine, citrulline and nitric oxide metabolism in sepsis

CC Kao, V Bandi, KK Guntupalli, M Wu… - Clinical …, 2009 - portlandpress.com
Arginine has vasodilatory effects, via its conversion by NO synthase into NO, and
immunomodulatory actions which play important roles in sepsis. Protein breakdown affects arginine …

[HTML][HTML] Increased mitochondrial arginine metabolism supports bioenergetics in asthma

…, BB Graham, KA Queisser, CC Kao… - The Journal of …, 2016 - Am Soc Clin Investig
High levels of arginine metabolizing enzymes, including inducible nitric oxide synthase (iNOS)
and arginase (ARG), are typical in asthmatic airway epithelium; however, little is known …

[HTML][HTML] Detection, classification, and management of rejection after lung transplantation

AD Parulekar, CC Kao - Journal of thoracic disease, 2019 - ncbi.nlm.nih.gov
Rejection is a major complication following lung transplantation. Acute cellular rejection,
lymphocytic bronchiolitis, and antibody-mediated rejection (AMR) are all risk factors for the …

Targeting the interleukin-4 and interleukin-13 pathways in severe asthma: current knowledge and future needs

AD Parulekar, CC Kao, Z Diamant… - Current opinion in …, 2018 - journals.lww.com
No biologic targeting the IL-4/IL-13 pathway is currently available for treatment of asthma, but
emerging data suggest that biologics targeting IL-4 and IL-13 together may benefit patients …

Resting energy expenditure and protein turnover are increased in patients with severe chronic obstructive pulmonary disease

CC Kao, JWC Hsu, V Bandi, NA Hanania… - Metabolism, 2011 - Elsevier
The mechanisms leading to weight loss in patients with chronic obstructive pulmonary
disease (COPD) are poorly understood. Changes in protein metabolism and systemic …

Fungal sensitization is associated with increased risk of life-threatening asthma

SK Medrek, CC Kao, DH Yang, NA Hanania… - The Journal of Allergy …, 2017 - Elsevier
Background Fungal sensitization in patients with asthma has been associated with severe
asthma and worse asthma outcomes. Objective The purpose of this study was to determine …

Alterations in glutamine metabolism and its conversion to citrulline in sepsis

C Kao, J Hsu, V Bandi, F Jahoor - American Journal of …, 2013 - journals.physiology.org
In enterocytes, glutamine serves as the major source of energy; another metabolic fate of
glutamine is conversion to citrulline. Because sepsis can affect gut function and integrity, …

[HTML][HTML] Shot-noise limited faraday rotation spectroscopy for detection of nitric oxide isotopes in Breath, Urine and Blood

…, F Cikach, J Barnes, S Comhair, RA Dweik, C Kao… - Scientific Reports, 2015 - nature.com
Measurement of NO and/or its metabolites in the various body compartments has transformed
our understanding of biology. The inability of the current NO measurement methods to …

[HTML][HTML] Predictors and patterns of weight gain during treatment for tuberculosis in the United States of America

MN Phan, ES Guy, RN Nickson, CC Kao - International Journal of Infectious …, 2016 - Elsevier
Objectives Patients with tuberculosis (TB) often present with weight loss. Lack of weight gain
with TB treatment has been associated with treatment failure. The purpose of this study was …

[HTML][HTML] The microbiome, intestinal function, and arginine metabolism of healthy Indian women are different from those of American and Jamaican women

CC Kao, JL Cope, JW Hsu, P Dwarkanath… - The Journal of …, 2016 - Elsevier
Background: Indian women have slower arginine flux during pregnancy compared with
American and Jamaican women. Arginine is a semi-essential amino acid that becomes essential …