[HTML][HTML] Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation
…, O Papantonopoulou, C Geyer… - The Journal of …, 2018 - Am Soc Clin Investig
Autoimmune diseases, such as psoriasis and arthritis, show a patchy distribution of
inflammation despite systemic dysregulation of adaptive immunity. Thus, additional tissue-derived …
inflammation despite systemic dysregulation of adaptive immunity. Thus, additional tissue-derived …
[HTML][HTML] Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity
…, S Hermann, P Van Lent, A Faust, C Geyer… - Nature …, 2014 - nature.com
Inflammation has a key role in the pathogenesis of various human diseases. The early detection,
localization and monitoring of inflammation are crucial for tailoring individual therapies. …
localization and monitoring of inflammation are crucial for tailoring individual therapies. …
[HTML][HTML] Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression
…, M Schulz, C Binder, J Tio, U Hansen, C Geyer… - Cell Communication and …, 2023 - Springer
Background Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which
they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a …
they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a …
[HTML][HTML] Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy
…, U Hansen, K Kronenberg, M Masthoff, C Geyer… - Breast Cancer …, 2023 - Springer
Background Response assessment of targeted cancer therapies is becoming increasingly
challenging, as it is not adequately assessable with conventional morphological and …
challenging, as it is not adequately assessable with conventional morphological and …
[HTML][HTML] Structural cartilage damage attracts circulating rheumatoid arthritis synovial fibroblasts into affected joints
J Hillen, C Geyer, M Heitzmann, D Beckmann… - Arthritis research & …, 2017 - Springer
Background Rheumatoid arthritis synovial fibroblasts (RASFs) are known to travel via the
bloodstream from sites of cartilage destruction to new locations where they reinitiate the …
bloodstream from sites of cartilage destruction to new locations where they reinitiate the …
[HTML][HTML] Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI
…, S Niland, R Niehoff, M Masthoff, C Geyer… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background The inflammatory tumor microenvironment (TME) is formed by various immune
cells, being closely associated with tumorigenesis. Especially, the interaction between tumor-…
cells, being closely associated with tumorigenesis. Especially, the interaction between tumor-…
[HTML][HTML] Multiparametric MRI enables for differentiation of different degrees of malignancy in two murine models of breast cancer
…, U Hansen, M Masthoff, A Helfen, C Geyer… - Frontiers in …, 2022 - frontiersin.org
Objective: The objective of this study was to non-invasively differentiate the degree of
malignancy in two murine breast cancer models based on identification of distinct tissue …
malignancy in two murine breast cancer models based on identification of distinct tissue …
Optical in vivo imaging of the alarmin S100A9 in tumor lesions allows for estimation of the individual malignant potential by evaluation of tumor–host cell interaction
…, K Barzcyk, G Varga, J Roth, C Geyer… - Journal of nuclear …, 2015 - Soc Nuclear Med
Tumors recruit and reprogram immune cells to support tumor development and spread, the
most prominent among them being of monocytic origin such as tumor-associated …
most prominent among them being of monocytic origin such as tumor-associated …
[HTML][HTML] Multiparametric chemical exchange saturation transfer MRI detects metabolic changes in breast cancer following immunotherapy
…, T Krähling, K Bergander, M Grewer, C Geyer… - Journal of Translational …, 2023 - Springer
Background With metabolic alterations of the tumor microenvironment (TME) contributing to
cancer progression, metastatic spread and response to targeted therapies, non-invasive and …
cancer progression, metastatic spread and response to targeted therapies, non-invasive and …
Exploring the influence of different albumin binders on molecular imaging probe distribution
C Höltke, M Grewer, M Stölting, C Geyer… - Molecular …, 2021 - ACS Publications
The biodistribution of molecular imaging probes or tracers mainly depends on the chemical
nature of the probe and the preferred metabolization and excretion routes. Small molecules …
nature of the probe and the preferred metabolization and excretion routes. Small molecules …