Advances in multiplexed imaging technologies have drastically improved our ability to
characterize healthy and diseased tissues at the single-cell level. Co-detection by indexing (…

Antitumoral immunity requires organized, spatially nuanced interactions between components
of the immune tumor microenvironment (iTME). Understanding this coordinated behavior …

Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the underlying …

3D visualization technologies such as virtual reality (VR), augmented reality (AR), and
mixed reality (MR) have gained popularity in the recent decade. Digital extended reality (XR) …

The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

Chronic myeloid leukemia (CML) is a malignant myeloproliferative disease with a characteristic
chronic phase (cp) of several years before progression to blast crisis (bc). The immune …

Neutropenia is probably the strongest known predisposition to infection with otherwise harmless
environmental or microbiota-derived species. Because initial swarming of neutrophils at …

The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory
disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the …

Cytotoxic CD8 + T cells (CTLs) play a major role in host defense against intracellular
pathogens, but a complete clearance of pathogens and return to homeostasis requires the …

Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective
treatments. While a subset of patients derive benefit from PD-1 blockade, there is a critically …