Background Treatment with cetuximab, a monoclonal antibody directed against the epidermal
growth factor receptor, improves overall and progression-free survival and preserves the …

Background Cetuximab, an IgG1 chimeric monoclonal antibody against epidermal growth
factor receptor (EGFR), has activity against colorectal cancers that express EGFR. Methods …

Background Local recurrence rates in operable rectal cancer are improved by radiotherapy (with
or without chemotherapy) and surgical techniques such as total mesorectal excision. …

Context Patients with metastatic colorectal cancer who have KRAS codon 12– or KRAS codon
13–mutated tumors are presently excluded from treatment with the anti–epidermal growth …

Leukocyte activation can be negatively regulated by inhibitory receptors specific for MHC
class I molecules. While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all …

Purpose Limited data are available on the time course of treatment failures (recurrence and/or
death), the nature and duration of adjuvant treatment benefit, and long-term recurrence …

Purpose Adjuvant systemic chemotherapy administered after surgical resection of colorectal
cancer metastases may reduce the risk of recurrence and improve survival, but its benefit …

Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent
host, but remains a major cause of morbidity in immunosuppressed individuals. Using the …

EBV is a gammaherpesvirus that can establish both nonproductive (latent) and productive (lytic)
infections within the cells of its host. Although T cell responses to EBV latent proteins …

HLA-B27 has a striking association with inflammatory arthritis. We show that free HLA-B27
heavy chains can form a disulfide-bonded homodimer, dependent on residue Cys 67 in their …