[PDF][PDF] High-contrast in vivo imaging of tau pathologies in Alzheimer's and non-Alzheimer's disease tauopathies
…, M Ono, M Kubota, S Kitamura, K Takahata, C Seki… - Neuron, 2021 - cell.com
A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau
pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal lobar …
pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal lobar …
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs)
afford remotely reversible control of cellular signaling, neuronal activity and …
afford remotely reversible control of cellular signaling, neuronal activity and …
PET quantification of tau pathology in human brain with 11C-PBB3
…, H Ito, H Shimada, Y Ikoma, C Seki… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Tau accumulation in the brain is a pathologic hallmark of Alzheimer disease and other
tauopathies. Quantitative visualization of tau pathology in humans can be a powerful method as a …
tauopathies. Quantitative visualization of tau pathology in humans can be a powerful method as a …
Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I
…, Y Kimura, R Arakawa, H Takano, C Seki… - Journal of Nuclear …, 2012 - Soc Nuclear Med
18 F-(E)-N-(3-iodoprop-2E-enyl)-2β-carbofluoroethoxy-3β-(4-methylphenyl)nortropane ( 18
F-FE-PE2I) is a new PET radioligand with a high affinity and selectivity for the dopamine …
F-FE-PE2I) is a new PET radioligand with a high affinity and selectivity for the dopamine …
Age-related decline of dopamine synthesis in the living human brain measured by positron emission tomography with L-[β-11C] DOPA
M Ota, F Yasuno, H Ito, C Seki, S Nozaki, T Asada… - Life sciences, 2006 - Elsevier
Loss of dopamine synthesis in the striatum with normal human aging has been observed in
the postmortem brain. To investigate whether there is age-associated change in dopamine …
the postmortem brain. To investigate whether there is age-associated change in dopamine …
PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute …
X Zhou, B Ji, C Seki, Y Nagai… - Journal of Cerebral …, 2021 - journals.sagepub.com
Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. In this
study, we developed a novel PET radioligand for CSF1R, 11 C-GW2580, and compared it to a …
study, we developed a novel PET radioligand for CSF1R, 11 C-GW2580, and compared it to a …
Visualization of AMPA receptors in living human brain with positron emission tomography
…, Y Ishiwata, M Sonoda, M Tokunaga, C Seki… - Nature medicine, 2020 - nature.com
Although aberrations in the number and function of glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole
propionic acid) receptors are thought to underlie neuropsychiatric …
propionic acid) receptors are thought to underlie neuropsychiatric …
Selective disruption of inhibitory synapses leading to neuronal hyperexcitability at an early stage of tau pathogenesis in a mouse model
…, K Minatohara, M Ono, C Seki… - Journal of …, 2020 - Soc Neuroscience
Synaptic dysfunction provoking dysregulated cortical neural circuits is currently hypothesized
as a key pathophysiological process underlying clinical manifestations in Alzheimer's …
as a key pathophysiological process underlying clinical manifestations in Alzheimer's …
[HTML][HTML] Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism
…, K Tagai, Y Yamamoto, H Shimada, C Seki… - Scientific Reports, 2023 - nature.com
Increased excitatory neuronal tones have been implicated in autism, but its mechanism remains
elusive. The amplified glutamate signals may arise from enhanced glutamatergic circuits…
elusive. The amplified glutamate signals may arise from enhanced glutamatergic circuits…
Binding of Dopamine D1 Receptor and Noradrenaline Transporter in Individuals with Autism Spectrum Disorder: A PET Study
…, Y Yamamoto, H Shimada, Y Takado, C Seki… - Cerebral …, 2020 - academic.oup.com
Although previous studies have suggested the involvement of dopamine (DA) and noradrenaline
(NA) neurotransmissions in the autism spectrum disorder (ASD) pathophysiology, few …
(NA) neurotransmissions in the autism spectrum disorder (ASD) pathophysiology, few …