Copper is an essential trace element required by all living organisms. Excess amounts of
copper, however, results in cellular damage. Disruptions to normal copper homeostasis are …

In this review, we discuss genetic disorders involving altered coppermetabolism, particularly
in relation to Menkes disease (MD), occipital horn syndrome (OHS), and Wilson’s disease (…

The role of fibrocytes in wound angiogenesis remains unclear. We therefore demonstrated
the specific changes in fibrocyte accumulation for angiogesis in basic fibroblast growth factor (…

Genetic disorders of copper metabolism, including Menkes kinky hair disease (MD),
occipital horn syndrome (OHS) and Wilson’s disease (WD) are reviewed with a focus on the …

Menkes disease (MD) is an X-linked recessive disorder caused by mutations in ATP7A.
Patients with MD exhibit severe neurological and connective tissue disorders due to copper …

Menkes disease (MD), an X-linked recessive disorder of copper metabolism caused by
mutations in the copper-transporting ATP7A gene, results in growth failure and severe …

NC/Nga mice raised in nonsterile circumstances spontaneously suffer from atopic dermatitis-like
skin lesions with IgE hyperproduction. We investigated effects of rIL-12 on the IgE …

Menkes disease (MD) is a genetic neurodegenerative disorder characterized by copper
deficiency due to a defect in ATP7A. Standard treatment involves parenteral copper–histidine …

To investigate the crucial role of platelet-derived thromboxane A 2 (TXA 2) in initiating Ag-specific
contact sensitivity (CS), a platelet-dependent CS model using genetically mast cell-…

We present the first reported case of Menkes disease caused by an Alu element insertion
mutation that interfered with splicing regulatory elements. A whole young AluYa5a2 element, …