Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers
Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies
show reversible downregulation of brain cannabinoid CB 1 (cannabinoid receptor type 1) …
show reversible downregulation of brain cannabinoid CB 1 (cannabinoid receptor type 1) …
In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease
…, J Snow, KJ Jenko, N Kimura, W Corona, CL Morse… - Brain, 2013 - academic.oup.com
Neuroinflammation is a pathological hallmark of Alzheimer’s disease, but its role in cognitive
impairment and its course of development during the disease are largely unknown. To …
impairment and its course of development during the disease are largely unknown. To …
Comparison of [11C]-(R)-PK 11195 and [11C] PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission …
…, N Kimura, KJ Jenko, P Kannan, J Hong, CL Morse… - Neuroimage, 2010 - Elsevier
Ten percent of humans lack specific binding of [ 11 C]PBR28 to 18 kDa translocator protein (TSPO),
a biomarker for inflammation. “Non-binders” have not been reported using another …
a biomarker for inflammation. “Non-binders” have not been reported using another …
A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of …
…, CH Lyoo, W Corona, CL Morse… - Journal of Cerebral …, 2013 - journals.sagepub.com
Second-generation radioligands for translocator protein (TSPO), an inflammation marker,
are confounded by the codominant rs6971 polymorphism that affects binding affinity. The …
are confounded by the codominant rs6971 polymorphism that affects binding affinity. The …
Cerebellum can serve as a pseudo-reference region in Alzheimer disease to detect neuroinflammation measured with PET radioligand binding to translocator protein
…, M Ikawa, JS Liow, SS Zoghbi, CL Morse… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Alzheimer disease (AD) is associated with an increase in the brain of the 18-kDa translocator
protein (TSPO), which is overexpressed in activated microglia and reactive astrocytes. …
protein (TSPO), which is overexpressed in activated microglia and reactive astrocytes. …
11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease
…, M Wei, J Snow, E Page, KJ Jenko, CL Morse… - Neurobiology of …, 2016 - Elsevier
This longitudinal study sought to determine whether the 18 kDa translocator protein (TSPO),
a marker of neuroinflammation, increases over time in Alzheimer's disease. Positron …
a marker of neuroinflammation, increases over time in Alzheimer's disease. Positron …
Neuroinflammation in temporal lobe epilepsy measured using positron emission tomographic imaging of translocator protein
Importance Neuroinflammation may play a role in epilepsy. Translocator protein 18 kDa (TSPO),
a biomarker of neuroinflammation, is overexpressed on activated microglia and reactive …
a biomarker of neuroinflammation, is overexpressed on activated microglia and reactive …
P-glycoprotein function at the blood–brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide
…, N Seneca, SS Zoghbi, CL Morse… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Permeability-glycoprotein (P-gp), an efflux transporter in several organs, acts at the blood–brain
barrier to protect the brain from exogenous toxins. P-gp almost completely blocks brain …
barrier to protect the brain from exogenous toxins. P-gp almost completely blocks brain …
Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography
Brain cannabinoid CB 1 receptors contribute to alcohol-related behaviors in experimental
animals, but their potential role in humans with alcohol dependence is poorly understood. We …
animals, but their potential role in humans with alcohol dependence is poorly understood. We …
Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using 18F-labeled inverse agonist radioligands
…, L Phebus, CC Felder, CL Morse… - Journal of Nuclear …, 2010 - Soc Nuclear Med
We recently demonstrated that 11 C-MePPEP, a PET ligand for CB 1 receptors, has such high
uptake in the human brain that it can be imaged for 210 min and that receptor density can …
uptake in the human brain that it can be imaged for 210 min and that receptor density can …