In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease
…, J Snow, KJ Jenko, N Kimura, W Corona, CL Morse… - Brain, 2013 - academic.oup.com
Neuroinflammation is a pathological hallmark of Alzheimer’s disease, but its role in cognitive
impairment and its course of development during the disease are largely unknown. To …
impairment and its course of development during the disease are largely unknown. To …
Comparison of [11C]-(R)-PK 11195 and [11C] PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission …
…, N Kimura, KJ Jenko, P Kannan, J Hong, CL Morse… - Neuroimage, 2010 - Elsevier
Ten percent of humans lack specific binding of [ 11 C]PBR28 to 18 kDa translocator protein (TSPO),
a biomarker for inflammation. “Non-binders” have not been reported using another …
a biomarker for inflammation. “Non-binders” have not been reported using another …
A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of …
…, CH Lyoo, W Corona, CL Morse… - Journal of Cerebral …, 2013 - journals.sagepub.com
Second-generation radioligands for translocator protein (TSPO), an inflammation marker,
are confounded by the codominant rs6971 polymorphism that affects binding affinity. The …
are confounded by the codominant rs6971 polymorphism that affects binding affinity. The …
Cerebellum can serve as a pseudo-reference region in Alzheimer disease to detect neuroinflammation measured with PET radioligand binding to translocator protein
…, M Ikawa, JS Liow, SS Zoghbi, CL Morse… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Alzheimer disease (AD) is associated with an increase in the brain of the 18-kDa translocator
protein (TSPO), which is overexpressed in activated microglia and reactive astrocytes. …
protein (TSPO), which is overexpressed in activated microglia and reactive astrocytes. …
11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease
…, M Wei, J Snow, E Page, KJ Jenko, CL Morse… - Neurobiology of …, 2016 - Elsevier
This longitudinal study sought to determine whether the 18 kDa translocator protein (TSPO),
a marker of neuroinflammation, increases over time in Alzheimer's disease. Positron …
a marker of neuroinflammation, increases over time in Alzheimer's disease. Positron …
Neuroinflammation in temporal lobe epilepsy measured using positron emission tomographic imaging of translocator protein
Importance Neuroinflammation may play a role in epilepsy. Translocator protein 18 kDa (TSPO),
a biomarker of neuroinflammation, is overexpressed on activated microglia and reactive …
a biomarker of neuroinflammation, is overexpressed on activated microglia and reactive …
P-glycoprotein function at the blood–brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide
…, N Seneca, SS Zoghbi, CL Morse… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Permeability-glycoprotein (P-gp), an efflux transporter in several organs, acts at the blood–brain
barrier to protect the brain from exogenous toxins. P-gp almost completely blocks brain …
barrier to protect the brain from exogenous toxins. P-gp almost completely blocks brain …
Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using 18F-labeled inverse agonist radioligands
…, L Phebus, CC Felder, CL Morse… - Journal of Nuclear …, 2010 - Soc Nuclear Med
We recently demonstrated that 11 C-MePPEP, a PET ligand for CB 1 receptors, has such high
uptake in the human brain that it can be imaged for 210 min and that receptor density can …
uptake in the human brain that it can be imaged for 210 min and that receptor density can …
Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand
…, JM Schaus, L Phebus, CC Felder, CL Morse… - Neuroimage, 2009 - Elsevier
[ 11 C]MePPEP is a high affinity, CB 1 receptor-selective, inverse agonist that has been
studied in rodents and monkeys. We examined the ability of [ 11 C]MePPEP to quantify CB 1 …
studied in rodents and monkeys. We examined the ability of [ 11 C]MePPEP to quantify CB 1 …
Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A
TG Lohith, SS Zoghbi, CL Morse… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Nociceptin/orphanin FQ peptide (NOP) receptor is a new class of opioid receptor that may
play a pathophysiologic role in anxiety and drug abuse and is a potential therapeutic target in …
play a pathophysiologic role in anxiety and drug abuse and is a potential therapeutic target in …