Sphingosine 1-phosphate (S1P), a multifunctional lipid mediator, regulates lymphocyte
trafficking, vascular permeability, and angiogenesis by activation of the S1P 1 receptor. This …

Matriptase is an epithelial-derived, integral membrane serine protease. The enzyme was
initially isolated from human breast cancer cells and has been implicated in breast cancer …

Seprase, a large, gelatin-degrading membrane-protease complex, is expressed at the invasive
front of malignant melanoma cells on invadopodia, and its surface expression contributes …

Matriptase, a trypsin-like serine protease with two potential regulatory modules (low density
lipoprotein receptor and complement C1r/s domains), was initially purified from T-47D breast …

Numerous studies have demonstrated that overexpression of Met, the hepatocyte growth
factor(HGF) receptor, plays an important role in tumorigenesis. Met activation can either occur …

A major protease from human breast cancer cells was previously detected by gelatin
zymography and proposed to play a role in breast cancer invasion and metastasis. To structurally …

TMPRSS2, a type II transmembrane serine protease, is highly expressed by the epithelium
of the human prostate gland. To explore the regulation and function of TMPRSS2 in the …

The activation of matriptase requires proteolytic cleavage at a canonical activation motif that
converts the enzyme from a one-chain zymogen to an active, two-chain protease. In this …

Purpose: Matriptase is a type II transmembrane serine protease expressed by cells of surface
epithelial origin, including epithelial ovarian tumor cells. Matriptase cleaves and activates …

Recent gene ablation studies in mice have shown that matriptase, a type II transmembrane
serine protease, and prostasin, a glycosylphosphatidylinositol-anchored membrane serine …