Effects of hypoxia on expression of a panel of stem cell and chemoresistance markers in glioblastoma-derived spheroids
J Kolenda, SS Jensen, C Aaberg-Jessen… - Journal of neuro …, 2011 - Springer
Tumor hypoxia has been attributed to play a crucial role in tumorigenesis and therapeutic
resistance. Recently, it has been suggested that hypoxia leads to and maintains the …
resistance. Recently, it has been suggested that hypoxia leads to and maintains the …
[HTML][HTML] Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas
RK Ramachandran, MD Sørensen, C Aaberg-Jessen… - PLoS …, 2017 - journals.plos.org
Astrocytomas are the most frequent primary brain tumors in adults, and despite aggressive
treatment patients often experience recurrence. Survival decreases with increasing tumor …
treatment patients often experience recurrence. Survival decreases with increasing tumor …
Low expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in glioblastoma predicts longer patient survival
C Aaberg-Jessen, K Christensen, H Offenberg… - Journal of neuro …, 2009 - Springer
In colorectal cancer and breast cancer a high TIMP-1 level has been shown to correlate with
a shorter overall patient survival and it has been suggested that TIMP-1 is involved in …
a shorter overall patient survival and it has been suggested that TIMP-1 is involved in …
miR-21 is linked to glioma angiogenesis: a co-localization study
…, BS Nielsen, C Aaberg-Jessen… - … of histochemistry & …, 2016 - journals.sagepub.com
MicroRNA-21 (miR-21) is the most consistently over-expressed microRNA (miRNA) in malignant
gliomas. We have previously reported that miR-21 is upregulated in glioma vessels and …
gliomas. We have previously reported that miR-21 is upregulated in glioma vessels and …
[HTML][HTML] Invasion of primary glioma-and cell line-derived spheroids implanted into corticostriatal slice cultures
C Aaberg-Jessen, A Nørregaard… - … journal of clinical and …, 2013 - ncbi.nlm.nih.gov
Gliomas are highly invasive tumors and the pronounced invasive features of gliomas prevent
radical surgical resection. In the search for new therapeutics targeting invasive glioma cells…
radical surgical resection. In the search for new therapeutics targeting invasive glioma cells…
[HTML][HTML] Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas
SS Jensen, C Aaberg-Jessen… - … journal of clinical and …, 2013 - ncbi.nlm.nih.gov
Targeting of lysosomes is a novel therapeutic anti-cancer strategy for killing the otherwise
apoptosis-resistant cancer cells. Such strategies are urgently needed for treatment of brain …
apoptosis-resistant cancer cells. Such strategies are urgently needed for treatment of brain …
[HTML][HTML] Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas
C Aaberg-Jessen, MD Sørensen, ALSA Matos… - BMC cancer, 2018 - Springer
Background We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1)
as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy …
as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy …
Immunohistochemical expression of stem cell, endothelial cell, and chemosensitivity markers in primary glioma spheroids cultured in serum-containing and serum-free …
K Christensen, C Aaberg-Jessen, C Andersen… - …, 2010 - journals.lww.com
OBJECTIVE: To investigate the influence of serum-free medium (SFM) supplemented with
epidermal growth factor and basic fibroblast growth factor compared with conventional serum-…
epidermal growth factor and basic fibroblast growth factor compared with conventional serum-…
[HTML][HTML] Establishment and characterization of a tumor stem cell-based glioblastoma invasion model
…, B Halle, AM Rosager, C Aaberg-Jessen… - PloS one, 2016 - journals.plos.org
Aims Glioblastoma is the most frequent and malignant brain tumor. Recurrence is inevitable
and most likely connected to tumor invasion and presence of therapy resistant stem-like …
and most likely connected to tumor invasion and presence of therapy resistant stem-like …
Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept
B Halle, EG Marcusson, C Aaberg-Jessen… - Journal of neuro …, 2016 - Springer
Over-expressed microRNAs (miRs) are promising new targets in glioblastoma (GBM) therapy.
Inhibition of over-expressed miRs has been shown to diminish GBM proliferation, invasion …
Inhibition of over-expressed miRs has been shown to diminish GBM proliferation, invasion …