Tumor imaging using a picomolar affinity HER2 binding affibody molecule
…, B Larsson, I Höidén-Guthenberg, C Widström… - Cancer research, 2006 - AACR
The detection of cell-bound proteins that are produced due to aberrant gene expression in
malignant tumors can provide important diagnostic information influencing patient …
malignant tumors can provide important diagnostic information influencing patient …
Individualized dosimetry of kidney and bone marrow in patients undergoing 177Lu-DOTA-octreotate treatment
…, D Granberg, S Johansson, C Widström… - Journal of Nuclear …, 2013 - Soc Nuclear Med
The organs at risk in radionuclide therapy with 177 Lu-octreotate are the bone marrow and
the kidneys. The primary aim of this study was to develop an individualized dosimetry …
the kidneys. The primary aim of this study was to develop an individualized dosimetry …
Targeting of HER2-expressing tumors with a site-specifically 99mTc-labeled recombinant affibody molecule, ZHER2: 2395, with C-terminally engineered cysteine
…, H Wållberg, TA Tran, C Widström… - Journal of Nuclear …, 2009 - Soc Nuclear Med
The detection of human epidermal growth factor receptor type 2 (HER2) expression in
malignant tumors provides important information influencing patient management. Radionuclide …
malignant tumors provides important information influencing patient management. Radionuclide …
111In-benzyl-DTPA–ZHER2: 342, an affibody-based conjugate for in vivo imaging of HER2 expression in malignant tumors
V Tolmachev, FY Nilsson, C Widström… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Data on expression of the HER2 (erbB-2) receptor in breast carcinoma make it possible to
select the most efficient treatment. There are strong indications that HER2 expression …
select the most efficient treatment. There are strong indications that HER2 expression …
Molecular design and optimization of 99mTc-labeled recombinant affibody molecules improves their biodistribution and imaging properties
…, M Altai, SJ Hosseinimehr, C Widström… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Affibody molecules are a recently developed class of targeting proteins based on a
nonimmunoglobulin scaffold. The small size (7 kDa) and subnanomolar affinity of Affibody molecules …
nonimmunoglobulin scaffold. The small size (7 kDa) and subnanomolar affinity of Affibody molecules …
Comparative in vivo evaluation of technetium and iodine labels on an anti-HER2 affibody for single-photon imaging of HER2 expression in tumors
…, FY Nilsson, M Wikman, C Widström… - Journal of Nuclear …, 2006 - Soc Nuclear Med
In vivo diagnosis with cancer-specific targeting agents that have optimal characteristics for
imaging is an important development in treatment planning for cancer patients. …
imaging is an important development in treatment planning for cancer patients. …
Irradiation-induced expression of hyaluronan (HA) synthase 2 and hyaluronidase 2 genes in rat lung tissue accompanies active turnover of HA and induction of types I …
Y Li, M Rahmanian, C Widstrom… - American Journal of …, 2000 - atsjournals.org
Hyaluronan (HA) is a linear glycosaminoglycan that accumulates in the interstitium of
injured lung and inhibits gas exchange between air and blood. In the present study we …
injured lung and inhibits gas exchange between air and blood. In the present study we …
Imaging of HER2-expressing tumours using a synthetic Affibody molecule containing the 99mTc-chelating mercaptoacetyl-glycyl-glycyl-glycyl (MAG3) sequence
Purpose Expression of human epidermal growth factor receptor type 2 (HER2) in malignant
tumours possesses well-documented prognostic and predictive value. Non-invasive imaging …
tumours possesses well-documented prognostic and predictive value. Non-invasive imaging …
99mTc-chelator engineering to improve tumour targeting properties of a HER2-specific Affibody molecule
Purpose Monitoring HER2 expression is crucial for selection of breast cancer patients
amenable to HER2-targeting therapy. The Affibody molecule Z HER2:342 binds to HER2 with …
amenable to HER2-targeting therapy. The Affibody molecule Z HER2:342 binds to HER2 with …
Development and preclinical characterisation of 99mTc-labelled Affibody molecules with reduced renal uptake
Purpose Affibody molecules are low molecular weight proteins (7 kDa), which can be selected
to bind to tumour-associated target proteins with subnanomolar affinity. Because of rapid …
to bind to tumour-associated target proteins with subnanomolar affinity. Because of rapid …