A role for norepinephrine in learning and memory has been elusive and controversial. A
longstanding hypothesis states that the adrenergic nervous system mediates enhanced memory …

Introduction The glymphatic system is a brain-wide perivascular network that facilitates
clearance of proteins, including amyloid β, from the brain interstitium through the perivascular …

Objectives To explore if short term, high dose vitamin D supplementation is safe and improves
balance in persons with Parkinson's disease (PD). Methods A pilot randomized, double-…

Centella asiatica (CA) herb is a traditional medicine, long reputed to provide cognitive benefits.
We have reported that CA water extract (CAW) treatment improves cognitive function of …

Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of
frontotemporal dementia. Most pathogenic GRN mutations result in progranulin …

Background Postoperative cognitive dysfunction (POCD) is a common postoperative
complication experienced by patients aged 65 years and older, and these older adults comprise …

Proteomic studies using postmortem human brain tissue samples have yielded robust
assessments of the aging and neurodegenerative disease(s) proteomes. While these analyses …

The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary
tangles is the histopathological hallmark of Alzheimer’s disease (AD). The glymphatic system, a …

Balance during stance is regulated by active control mechanisms that continuously estimate
body motion, via a “sensory integration” mechanism, and generate corrective actions, via a “…

Objective Biomarkers of Alzheimer disease vary between groups of self‐identified Black and
White individuals in some studies. This study examined whether the relationships between …