User profiles for Charles Chen

Charles H. Chen

Senior Scientist, Pharmaceutical Sciences, AstraZeneca
Verified email at astrazeneca.com
Cited by 922

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and …

…, LY Tang, D Wilkie, A McNabola, H Rong, C Chen… - Cancer research, 2004 - AACR
The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and
angiogenesis. The novel bi-aryl urea BAY 43-9006 is a potent inhibitor of Raf-1, a member of the …

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5

L Liu, Y Cao, C Chen, X Zhang, A McNabola, D Wilkie… - Cancer research, 2006 - AACR
Angiogenesis and signaling through the RAF/mitogen-activated protein/extracellular signal-regulated
kinase (ERK) kinase (MEK)/ERK cascade have been reported to play important …

Association between independent non-executive directors, family control and financial disclosures in Hong Kong

CJP Chen, B Jaggi - Journal of Accounting and Public policy, 2000 - Elsevier
Our study examines whether comprehensive financial disclosures, used as a proxy for
corporate board’s responsiveness, are positively associated with the proportion of independent …

Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models

…, D Xue, E Bortolon, M Ichetovkin, C Chen… - Cancer chemotherapy …, 2007 - Springer
Purpose New research findings have revealed a key role for vascular endothelial growth
factor (VEGF) in the stimulation of angiogenesis in clear cell renal carcinoma (RCC) which is a …

Discretionary accounting accruals, managers' incentives, and audit fees

FA Gul, CJP Chen, JSL Tsui - Contemporary accounting …, 2003 - Wiley Online Library
This paper examines the linkages between discretionary accruals (DAs), managerial share
ownership, management compensation, and audit fees. It draws on the theory that managers …

Rent-seeking incentives, corporate political connections, and the control structure of private firms: Chinese evidence

CJP Chen, Z Li, X Su, Z Sun - Journal of Corporate Finance, 2011 - Elsevier
We examine how the rent-seeking incentives of local government motivate private firms 1
listed in China to establish political connections, and whether such connections lead to more …

Professional issues: Common stressors among international college students: Research and counseling implications

CP Chen - Journal of college counseling, 1999 - Wiley Online Library
Charles p: Chen is a doctoral candidate and instructor in the Department of Counselling …
Correspondence regarding this article should be sent to Charles I? Chen. Department of …

Is accounting information value-relevant in the emerging Chinese stock market?

CJP Chen, S Chen, X Su - Journal of international accounting, auditing and …, 2001 - Elsevier
This study examines empirically whether domestic investors in the Chinese stock market
perceive accounting information based on Chinese GAAP to be value-relevant. The study is …

Profitability regulation, earnings management, and modified audit opinions: Evidence from China

CJP Chen, S Chen, X Su - Auditing: A Journal of Practice & …, 2001 - publications.aaahq.org
This study, using data from the Chinese stock market, investigates the relationship between
earnings management induced by profitability regulation and modified audit opinions (MAOs)…

High-level politically connected firms, corruption, and analyst forecast accuracy around the world

CJP Chen, Y Ding, C Kim - Journal of International Business Studies, 2010 - Springer
The international business (IB) literature has widely recognized political forces as major
factors that complicate the strategic decisions of multinational enterprises (MNEs). Analyses by …