User profiles for Charles Chen
Charles H. ChenSenior Scientist, Pharmaceutical Sciences, AstraZeneca Verified email at astrazeneca.com Cited by 922 |
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and …
…, LY Tang, D Wilkie, A McNabola, H Rong, C Chen… - Cancer research, 2004 - AACR
The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and
angiogenesis. The novel bi-aryl urea BAY 43-9006 is a potent inhibitor of Raf-1, a member of the …
angiogenesis. The novel bi-aryl urea BAY 43-9006 is a potent inhibitor of Raf-1, a member of the …
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
L Liu, Y Cao, C Chen, X Zhang, A McNabola, D Wilkie… - Cancer research, 2006 - AACR
Angiogenesis and signaling through the RAF/mitogen-activated protein/extracellular signal-regulated
kinase (ERK) kinase (MEK)/ERK cascade have been reported to play important …
kinase (ERK) kinase (MEK)/ERK cascade have been reported to play important …
Association between independent non-executive directors, family control and financial disclosures in Hong Kong
CJP Chen, B Jaggi - Journal of Accounting and Public policy, 2000 - Elsevier
Our study examines whether comprehensive financial disclosures, used as a proxy for
corporate board’s responsiveness, are positively associated with the proportion of independent …
corporate board’s responsiveness, are positively associated with the proportion of independent …
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
…, D Xue, E Bortolon, M Ichetovkin, C Chen… - Cancer chemotherapy …, 2007 - Springer
Purpose New research findings have revealed a key role for vascular endothelial growth
factor (VEGF) in the stimulation of angiogenesis in clear cell renal carcinoma (RCC) which is a …
factor (VEGF) in the stimulation of angiogenesis in clear cell renal carcinoma (RCC) which is a …
Discretionary accounting accruals, managers' incentives, and audit fees
FA Gul, CJP Chen, JSL Tsui - Contemporary accounting …, 2003 - Wiley Online Library
This paper examines the linkages between discretionary accruals (DAs), managerial share
ownership, management compensation, and audit fees. It draws on the theory that managers …
ownership, management compensation, and audit fees. It draws on the theory that managers …
Rent-seeking incentives, corporate political connections, and the control structure of private firms: Chinese evidence
CJP Chen, Z Li, X Su, Z Sun - Journal of Corporate Finance, 2011 - Elsevier
We examine how the rent-seeking incentives of local government motivate private firms 1
listed in China to establish political connections, and whether such connections lead to more …
listed in China to establish political connections, and whether such connections lead to more …
Professional issues: Common stressors among international college students: Research and counseling implications
CP Chen - Journal of college counseling, 1999 - Wiley Online Library
… Charles p: Chen is a doctoral candidate and instructor in the Department of Counselling …
Correspondence regarding this article should be sent to Charles I? Chen. Department of …
Correspondence regarding this article should be sent to Charles I? Chen. Department of …
Is accounting information value-relevant in the emerging Chinese stock market?
CJP Chen, S Chen, X Su - Journal of international accounting, auditing and …, 2001 - Elsevier
This study examines empirically whether domestic investors in the Chinese stock market
perceive accounting information based on Chinese GAAP to be value-relevant. The study is …
perceive accounting information based on Chinese GAAP to be value-relevant. The study is …
Profitability regulation, earnings management, and modified audit opinions: Evidence from China
CJP Chen, S Chen, X Su - Auditing: A Journal of Practice & …, 2001 - publications.aaahq.org
This study, using data from the Chinese stock market, investigates the relationship between
earnings management induced by profitability regulation and modified audit opinions (MAOs)…
earnings management induced by profitability regulation and modified audit opinions (MAOs)…
High-level politically connected firms, corruption, and analyst forecast accuracy around the world
The international business (IB) literature has widely recognized political forces as major
factors that complicate the strategic decisions of multinational enterprises (MNEs). Analyses by …
factors that complicate the strategic decisions of multinational enterprises (MNEs). Analyses by …